Methyl 3-[4-(4-chlorophenyl)piperazin-1-yl]propanoate

Base Information

Chemical Name:Methyl 3-[4-(4-chlorophenyl)piperazin-1-yl]propanoate
CAS No.:6269-51-8
Molecular Formula:C14H19ClN2O2
Molecular Weight:282.7659
Hs Code.:
NSC Number:33313
DSSTox Substance ID:DTXSID20283757
Wikidata:Q82018441

Synonyms:methyl 3-[4-(4-chlorophenyl)piperazin-1-yl]propanoate;6269-51-8;NSC33313;Oprea1_744214;DTXSID20283757;NSC-33313;SR-01000214588;SR-01000214588-1

Suppliers and Price of Methyl 3-[4-(4-chlorophenyl)piperazin-1-yl]propanoate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 5 raw suppliers

Chemical Property of Methyl 3-[4-(4-chlorophenyl)piperazin-1-yl]propanoate

Chemical Property:

Vapor Pressure:8.8E-07mmHg at 25°C
Boiling Point:405.4°Cat760mmHg
Flash Point:199°C
Density:1.184g/cm³
XLogP3:2.3
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:5
Exact Mass:282.1135055
Heavy Atom Count:19
Complexity:285

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:COC(=O)CCN1CCN(CC1)C2=CC=C(C=C2)Cl

Technology Process of Methyl 3-[4-(4-chlorophenyl)piperazin-1-yl]propanoate

There total 1 articles about Methyl 3-[4-(4-chlorophenyl)piperazin-1-yl]propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 38212-33-8
4-(4-chlorophenyl) piperazine

: 292638-85-8,9003-21-8,96-33-3
acrylic acid methyl ester

: 6269-51-8
3-[4-(4-chloro-phenyl)-piperazin-1-yl]-propionic acid methyl ester

Guidance literature:: In dichloromethane; at 20 ℃;
DOI:10.1016/j.ejmech.2020.113124

Reference yield:

: 6269-51-8
3-[4-(4-chloro-phenyl)-piperazin-1-yl]-propionic acid methyl ester

: 2-{2-[4-(4-chloro-phenyl)-piperazin-1-yl]-ethyl}-1H-pyrrolo[2,3-b]pyridine

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) n-BuLi / 1.) THF, from -15 deg C to -5 deg C, 2.) THF, from - 5 deg C to RT

2: HCl / 45 °C

With hydrogenchloride; n-butyllithium;
DOI:10.1016/S0960-894X(99)00025-6

Reference yield:

: 138343-75-6
tert-butyl (3-methylpyridin-2-yl)carbamate

: 6269-51-8
3-[4-(4-chloro-phenyl)-piperazin-1-yl]-propionic acid methyl ester

: (3-{4-[4-(4-chloro-phenyl)-piperazin-1-yl]-2-oxo-butyl}-pyridin-2-yl)-carbamic acid tert-butyl ester

Guidance literature:: With n-butyllithium; Multistep reaction; 1.) THF, from -15 deg C to -5 deg C, 2.) THF, from - 5 deg C to RT;
DOI:10.1016/S0960-894X(99)00025-6