1H-Imidazole-1-carboxylic acid, 2-[4-[[[[2-[[(2,3-dichlorophenyl)sulfonyl]methylamino]ethoxy]acetyl]methyl amino]methyl]phenyl]-4,5-dihydro-, 1,1-dimethylethyl ester

Base Information

Chemical Name:1H-Imidazole-1-carboxylic acid, 2-[4-[[[[2-[[(2,3-dichlorophenyl)sulfonyl]methylamino]ethoxy]acetyl]methyl amino]methyl]phenyl]-4,5-dihydro-, 1,1-dimethylethyl ester
CAS No.:633698-50-7
Molecular Formula:C27H34Cl2N4O6S
Molecular Weight:613.562
Hs Code.:

1H-Imidazole-1-carboxylic acid,
2-[4-[[[[2-[[(2,3-dichlorophenyl)sulfonyl]methylamino]ethoxy]acetyl]methyl
amino]methyl]phenyl]-4,5-dihydro-, 1,1-dimethylethyl ester

Synonyms:

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Chemical Property of 1H-Imidazole-1-carboxylic acid, 2-[4-[[[[2-[[(2,3-dichlorophenyl)sulfonyl]methylamino]ethoxy]acetyl]methyl amino]methyl]phenyl]-4,5-dihydro-, 1,1-dimethylethyl ester

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Technology Process of 1H-Imidazole-1-carboxylic acid, 2-[4-[[[[2-[[(2,3-dichlorophenyl)sulfonyl]methylamino]ethoxy]acetyl]methyl amino]methyl]phenyl]-4,5-dihydro-, 1,1-dimethylethyl ester

There total 9 articles about 1H-Imidazole-1-carboxylic acid, 2-[4-[[[[2-[[(2,3-dichlorophenyl)sulfonyl]methylamino]ethoxy]acetyl]methyl amino]methyl]phenyl]-4,5-dihydro-, 1,1-dimethylethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

: [2-[[(2,3-dichlorophenyl)sulfonyl]methylamino]ethoxy]acetic acid

: 441295-92-7
4,5-dihydro-2-[4-[(methylamino)methyl]phenyl]-1H-imidazole-1-carboxylic acid 1,1-dimethylethyl ester

: 633698-50-7
2-[4-[[[[2-[[(2,3-dichlorophenyl)sulfonyl]methylamino]ethoxy]acetyl]methylamino]methyl]phenyl]-4,5-dihydro-1H-imidazole-1-carboxylic acid 1,1-dimethylethyl ester

Guidance literature:: With 1-hydroxy-7-aza-benzotriazole; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 20 ℃; for 15h;
DOI:10.1021/jm2016057

Reference yield: 73.0%

: 633698-50-7
2-[4-[[[[2-[[(2,3-dichlorophenyl)sulfonyl]methylamino]ethoxy]acetyl]methylamino]methyl]phenyl]-4,5-dihydro-1H-imidazole-1-carboxylic acid 1,1-dimethylethyl ester

Guidance literature:

Reference yield:

: 82417-45-6
dichlorobenzenesulfonyl chloride

: 633698-50-7
2-[4-[[[[2-[[(2,3-dichlorophenyl)sulfonyl]methylamino]ethoxy]acetyl]methylamino]methyl]phenyl]-4,5-dihydro-1H-imidazole-1-carboxylic acid 1,1-dimethylethyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: triethylamine / dichloromethane / 15 h / 20 °C

2: tetrabutyl-ammonium chloride; sodium hydroxide / water; toluene / 0.5 h / 10 - 20 °C

3: water; lithium hydroxide / tetrahydrofuran / 15 h / 20 °C

4: 1-hydroxy-7-aza-benzotriazole; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 15 h / 20 °C

With 1-hydroxy-7-aza-benzotriazole; tetrabutyl-ammonium chloride; water; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; sodium hydroxide; lithium hydroxide; In tetrahydrofuran; dichloromethane; water; toluene;
DOI:10.1021/jm2016057