1-Isoquinolinemethanol,1,2,3,4-tetrahydro-7-hydroxy-2-[(3-hydroxy-4-methoxyphenyl)methyl]-6-methoxy-

Base Information

Chemical Name:1-Isoquinolinemethanol,1,2,3,4-tetrahydro-7-hydroxy-2-[(3-hydroxy-4-methoxyphenyl)methyl]-6-methoxy-
CAS No.:221000-98-2
Molecular Formula:C₁₉H₂₃NO₅
Molecular Weight:345.395
Hs Code.:
Mol file:221000-98-2.mol

Synonyms:(?à)-Heterocarpine; Heterocarpine

Suppliers and Price of 1-Isoquinolinemethanol,1,2,3,4-tetrahydro-7-hydroxy-2-[(3-hydroxy-4-methoxyphenyl)methyl]-6-methoxy-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1-Isoquinolinemethanol,1,2,3,4-tetrahydro-7-hydroxy-2-[(3-hydroxy-4-methoxyphenyl)methyl]-6-methoxy-

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 1-Isoquinolinemethanol,1,2,3,4-tetrahydro-7-hydroxy-2-[(3-hydroxy-4-methoxyphenyl)methyl]-6-methoxy-

There total 5 articles about 1-Isoquinolinemethanol,1,2,3,4-tetrahydro-7-hydroxy-2-[(3-hydroxy-4-methoxyphenyl)methyl]-6-methoxy- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 220935-97-7
7-Hydroxy-2-(3-hydroxy-4-methoxy-benzyl)-6-methoxy-1,2,3,4-tetrahydro-isoquinoline-1-carboxylic acid methyl ester

: 221000-98-2
2-(3-Hydroxy-4-methoxy-benzyl)-1-hydroxymethyl-6-methoxy-1,2,3,4-tetrahydro-isoquinolin-7-ol

Guidance literature:: With lithium aluminium tetrahydride; In tetrahydrofuran; for 1h;
DOI:10.1016/S0031-9422(98)00198-8

Reference yield:

: 1699-38-3
3-benzyloxy-4-methoxy-benzyl chloride

: 221000-98-2
2-(3-Hydroxy-4-methoxy-benzyl)-1-hydroxymethyl-6-methoxy-1,2,3,4-tetrahydro-isoquinolin-7-ol

Guidance literature:: Multi-step reaction with 5 steps

1: acetonitrile / 4 h / Heating

2: 88 percent / H₂O / 0.5 h

3: 76 percent / conc. HCl / 48 h / 4 °C

4: 68 percent / Amberlite / 14 h / 65 °C

5: LiAlH₄ / tetrahydrofuran / 1 h

With hydrogenchloride; lithium aluminium tetrahydride; Amberlite; In tetrahydrofuran; water; acetonitrile;
DOI:10.1016/S0031-9422(98)00198-8

Reference yield:

: 220935-96-6
1-carbamoyl-2-(3-hydroxy-4-methoxybenzyl)-7-hydroxy-6-methoxy-1,2,3,4-tetrahydroisoquinoline

: 221000-98-2
2-(3-Hydroxy-4-methoxy-benzyl)-1-hydroxymethyl-6-methoxy-1,2,3,4-tetrahydro-isoquinolin-7-ol

Guidance literature:: Multi-step reaction with 2 steps

1: 68 percent / Amberlite / 14 h / 65 °C

2: LiAlH₄ / tetrahydrofuran / 1 h

With lithium aluminium tetrahydride; Amberlite; In tetrahydrofuran;
DOI:10.1016/S0031-9422(98)00198-8