2-(Benzyloxy)-4-(chloromethyl)-1-methoxybenzene

Base Information

• Chemical Name: 2-(Benzyloxy)-4-(chloromethyl)-1-methoxybenzene
• CAS No.: 1699-38-3
• Molecular Formula: C15H15 Cl O2
• Molecular Weight: 262.736
• NSC Number: 131672
• DSSTox Substance ID: DTXSID50299629
• Nikkaji Number: J1.410.510G
• Wikidata: Q82042124
• Mol file: 1699-38-3.mol

Synonyms:1699-38-3;2-(benzyloxy)-4-(chloromethyl)-1-methoxybenzene;2-Benzyloxy-4-chloromethyl-1-methoxybenzene;4-(chloromethyl)-1-methoxy-2-phenylmethoxybenzene;NSC131672;SCHEMBL6672350;DTXSID50299629;WVWFKLUFYXQFHO-UHFFFAOYSA-N;3-benzyloxy-4-methoxybenzylchloride;3-benzyloxy-4-methoxybenzyl chloride;3-benzyloxy-4-methoxy-benzyl chloride;AKOS004907047;NSC-131672;2-benzyloxy-4-(chloromethyl)-1-methoxy-benzene;A811152

Chemical Property of 2-(Benzyloxy)-4-(chloromethyl)-1-methoxybenzene

Chemical Property:

• Vapor Pressure: 1.16E-05mmHg at 25°C
• Boiling Point: 380.8°Cat760mmHg
• Flash Point: 141.5°C
• PSA: 18.46000
• Density: 1.163g/cm³
• LogP: 4.01300
• XLogP3: 3.5
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 5
• Exact Mass: 262.0760574
• Heavy Atom Count: 18
• Complexity: 229

Purity/Quality:

97% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=C(C=C(C=C1)CCl)OCC2=CC=CC=C2

Technology Process of 2-(Benzyloxy)-4-(chloromethyl)-1-methoxybenzene

There total 9 articles about 2-(Benzyloxy)-4-(chloromethyl)-1-methoxybenzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

3-benzyloxy-4-methoxy-benzyl alcohol (1860-60-2) → 3-benzyloxy-4-methoxy-benzyl chloride (1699-38-3)

Guidance literature:

With thionyl chloride; In dichloromethane; for 0.5h;

Reference yield:

isovanillin (621-59-0) → 3-benzyloxy-4-methoxy-benzyl chloride (1699-38-3)

Guidance literature:

Multi-step reaction with 3 steps

1: 98 percent / K₂CO₃ / methanol / 5 h / Heating

2: 90 percent / NaBH₄ / methanol / 1 h / 20 °C

3: 85 percent / SOCl₂ / dioxane / 1 h / 20 °C

With sodium tetrahydroborate; thionyl chloride; potassium carbonate; In 1,4-dioxane; methanol;

DOI:10.1016/S0960-894X(01)00403-6

Reference yield:

3-benzyloxy-4-methoxybenzaldehyde (6346-05-0) → 3-benzyloxy-4-methoxy-benzyl chloride (1699-38-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 90 percent / NaBH₄ / methanol / 1 h / 20 °C

2: 85 percent / SOCl₂ / dioxane / 1 h / 20 °C

With sodium tetrahydroborate; thionyl chloride; In 1,4-dioxane; methanol;

DOI:10.1016/S0960-894X(01)00403-6

upstream raw materials:

3-benzyloxy-4-methoxy-benzyl alcohol

isovanillin

benzyl bromide

3-benzyloxy-4-methoxybenzaldehyde

Downstream raw materials:

2-(3-(benzyloxy)-4-methoxyphenyl)acetonitrile

3-Benzyloxy-4-methoxybenzylazid

6-benzoyl-5-(3-benzyloxy-4-methoxy-benzyl)-5,6-dihydro-[1,3]dioxolo[4,5-g]isoquinoline-5-carbonitrile

N-(3-benzyloxy-4-methoxybenzyl)aziridine