Technology Process of Benzenepropanol,
2-(methoxymethoxy)-a-[[5-methoxy-2-(methoxymethoxy)phenyl]methyl]-
There total 10 articles about Benzenepropanol,
2-(methoxymethoxy)-a-[[5-methoxy-2-(methoxymethoxy)phenyl]methyl]- which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: 84 percent / m-xylene / 180 °C
2.1: sodium hydride / dimethylformamide / 0.5 h / 0 °C
2.2: 80 percent / dimethylformamide / 1 h / 20 °C
3.1: 51 percent / osmium tetroxide; sodium periodate / tetrahydrofuran; H2O / 8.5 h / 0 - 20 °C
4.1: n-butyllithium / tetrahydrofuran / 0.5 h / -78 °C
4.2: 67 percent / tetrahydrofuran / -78 - 20 °C
5.1: 96 percent / potassium bicarbonate; hydrogen / palladium on carbon / ethyl acetate / 20 °C
With
sodium periodate; osmium(VIII) oxide; n-butyllithium; hydrogen; sodium hydride; potassium hydrogencarbonate;
palladium on activated charcoal;
In
tetrahydrofuran; water; ethyl acetate; N,N-dimethyl-formamide; m-xylene;
1.1: Claisen rearrangement;
DOI:10.1016/j.tet.2007.02.033
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: sodium hydride / dimethylformamide / 0.5 h / 0 °C
1.2: 80 percent / dimethylformamide / 1 h / 20 °C
2.1: 51 percent / osmium tetroxide; sodium periodate / tetrahydrofuran; H2O / 8.5 h / 0 - 20 °C
3.1: n-butyllithium / tetrahydrofuran / 0.5 h / -78 °C
3.2: 67 percent / tetrahydrofuran / -78 - 20 °C
4.1: 96 percent / potassium bicarbonate; hydrogen / palladium on carbon / ethyl acetate / 20 °C
With
sodium periodate; osmium(VIII) oxide; n-butyllithium; hydrogen; sodium hydride; potassium hydrogencarbonate;
palladium on activated charcoal;
In
tetrahydrofuran; water; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1016/j.tet.2007.02.033
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: 88 percent / triphenylphosphine; triethylamine; copper(I) iodide / bis(triphenylphosphine)palladium(II) chloride / 80 °C
2.1: 70 percent / sodium hydroxide / toluene / 3.5 h / Heating
3.1: n-butyllithium / tetrahydrofuran / 0.5 h / -78 °C
3.2: 67 percent / tetrahydrofuran / -78 - 20 °C
4.1: 96 percent / potassium bicarbonate; hydrogen / palladium on carbon / ethyl acetate / 20 °C
With
sodium hydroxide; copper(l) iodide; n-butyllithium; hydrogen; potassium hydrogencarbonate; triethylamine; triphenylphosphine;
palladium on activated charcoal; bis(triphenylphosphine)palladium(II)-chloride;
In
tetrahydrofuran; ethyl acetate; toluene;
1.1: Sonogashira coupling;
DOI:10.1016/j.tet.2007.02.033
