1,4:3,6-dianhydro-2,5-bis-O-(methylsulfonyl)hexitol

Base Information

Chemical Name:1,4:3,6-dianhydro-2,5-bis-O-(methylsulfonyl)hexitol
CAS No.:24808-23-9
Molecular Formula:C8H14 O8 S2
Molecular Weight:302.326
Hs Code.:
Mol file:24808-23-9.mol

Synonyms:Mannitol,1,4:3,6-dianhydro-, dimethanesulfonate, D- (8CI);Furo[3,2-b]furan, D-mannitolderiv.;NSC 83403;NSC 33695;Isomannide 2,5-dimethanesulfonate;

Suppliers and Price of 1,4:3,6-dianhydro-2,5-bis-O-(methylsulfonyl)hexitol

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
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price

Total 6 raw suppliers

Chemical Property of 1,4:3,6-dianhydro-2,5-bis-O-(methylsulfonyl)hexitol

Chemical Property:

Vapor Pressure:3.57E-12mmHg at 25°C
Refractive Index:1.536
Boiling Point:564.3°Cat760mmHg
Flash Point:295.1°C
Density:1.58g/cm³

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 1,4:3,6-dianhydro-2,5-bis-O-(methylsulfonyl)hexitol

There total 1 articles about 1,4:3,6-dianhydro-2,5-bis-O-(methylsulfonyl)hexitol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 641-74-7
1,4:3,6-dianhydro-D-mannitol

: 24808-23-9
1,4:3,6-dianhydro-2,5-bis-O-(methylsulfonyl)-D-mannitol

Guidance literature:: With pyridine; methanesulfonyl chloride;
DOI:10.1039/jr9480002204

Reference yield: 15.0%

: 3943-74-6
4-hydroxy-3-methoxybenzoic acid methyl ester

: 24808-23-9
1,4:3,6-dianhydro-2,5-bis-O-(methylsulfonyl)-D-mannitol

: 1,4:3,6-dianhydro-2-O-[4-(methyloxy)carbonyl-2-(methyloxy)phenyl]-5-O-(methylsulfonyl)-D-glucitol

Guidance literature:: With caesium carbonate; In N,N-dimethyl-formamide; at 100 ℃; for 2.5h;

Reference yield:

: 24808-23-9
1,4:3,6-dianhydro-2,5-bis-O-(methylsulfonyl)-D-mannitol

: 1,4:3,6-dianhydro-5-O-{4-[(3-chloro-2-fluorophenyl)amino]-6-(methyloxy)quinazolin-7-yl}-2-deoxy-2-fluoro-L-iditol

Guidance literature:: Multi-step reaction with 7 steps

1: caesium carbonate / N,N-dimethyl-formamide / 2.5 h / 100 °C

2: potassium fluoride / dimethyl sulfoxide / 12 h / 180 °C

3: sulfuric acid; nitric acid / dichloromethane / 0.67 h / 0 - 20 °C

4: hydrogen; palladium 10% on activated carbon / methanol / 12 h / 2585.81 Torr

5: ammonium formate / 2.5 h / 165 °C

6: oxalyl dichloride; N,N-dimethyl-formamide / chloroform / 1.17 h / Reflux

7: acetonitrile / 2.5 h / Reflux

With potassium fluoride; oxalyl dichloride; sulfuric acid; palladium 10% on activated carbon; hydrogen; nitric acid; ammonium formate; caesium carbonate; N,N-dimethyl-formamide; In methanol; dichloromethane; chloroform; dimethyl sulfoxide; N,N-dimethyl-formamide; acetonitrile;