2',3',5'-Tri-o-benzoyl-5-azacytidine

Base Information

• Chemical Name: 2',3',5'-Tri-o-benzoyl-5-azacytidine
• CAS No.: 28998-36-9
• Molecular Formula: C29H24 N4 O8
• Molecular Weight: 556.532
• UNII: KY8NK5JU5K
• Nikkaji Number: J88.582G
• Mol file: 28998-36-9.mol

Synonyms:KY8NK5JU5K;2',3',5'-Tri-o-benzoyl-5-azacytidine;UNII-KY8NK5JU5K;5-Azacytidine 2',3',5'-tribenzoate;NSC-291931;28998-36-9;1,3,5-Triazin-2(1H)-one, 4-amino-1-(2,3,5-tri-o-benzoyl-beta-D-ribofuranosyl)-;4-Amino-1-(2,3,5-tri-o-benzoyl-beta-D-ribofuranosyl)-1,3,5-triazin-2(1H)-one;5-azacytidine tribenzoate;SCHEMBL2295858;XMEBCSNOBVAIDQ-MOUTVQLLSA-N

Chemical Property of 2',3',5'-Tri-o-benzoyl-5-azacytidine

Chemical Property:

• Vapor Pressure: 5.31E-20mmHg at 25°C
• Boiling Point: 709.9°Cat760mmHg
• Flash Point: 383.1°C
• PSA: 161.93000
• Density: 1.43g/cm³
• LogP: 3.00730
• XLogP3: 3.6
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 8
• Rotatable Bond Count: 11
• Exact Mass: 556.15941374
• Heavy Atom Count: 41
• Complexity: 1030

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C(C=C1)C(=O)OCC2C(C(C(O2)N3C=NC(=NC3=O)N)OC(=O)C4=CC=CC=C4)OC(=O)C5=CC=CC=C5
• Isomeric SMILES: C1=CC=C(C=C1)C(=O)OC[C@@H]2[C@H]([C@H]([C@@H](O2)N3C=NC(=NC3=O)N)OC(=O)C4=CC=CC=C4)OC(=O)C5=CC=CC=C5
• Uses: 2'',3'',5''-Tri-O-Benzoyl-5-Azacytidine is an impurity of Azacytidine (A796000) a a demethylating agent by inhibiting DNA methyltransferase.

Technology Process of 2',3',5'-Tri-o-benzoyl-5-azacytidine

There total 2 articles about 2',3',5'-Tri-o-benzoyl-5-azacytidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-O-acetyl-2,3,5-tri-O-benzoyl-β-D-ribofuranose (6974-32-9) + 2-(trimethylsilylamino)-4-(trimethylsilyloxy)-s-triazine (52523-35-0) → 4-amino-1-(2,3,5-tri-O-benzoyl-β-D-ribofuranosyl)-1,3,5-triazin-2(1H)-one (28998-36-9)

Guidance literature:

With trimethylsilyl trifluoromethanesulfonate; In dichloromethane; at 0 - 20 ℃; for 4h; Inert atmosphere;

DOI:10.1007/s11094-016-1375-4

Reference yield:

→ 4-amino-1-(2,3,5-tri-O-benzoyl-β-D-ribofuranosyl)-1,3,5-triazin-2(1H)-one (28998-36-9)

Guidance literature:

Acetat 2,Triazin 1a,SnCl4;

DOI:10.1021/jo00939a011

Reference yield: 75.9%

4-amino-1-(2,3,5-tri-O-benzoyl-β-D-ribofuranosyl)-1,3,5-triazin-2(1H)-one (28998-36-9) → 5-azacytidine (320-67-2)

Guidance literature:

With sodium methylate; In methanol; for 2h; Inert atmosphere;

upstream raw materials:

1-O-acetyl-2,3,5-tri-O-benzoyl-β-D-ribofuranose

2-(trimethylsilylamino)-4-(trimethylsilyloxy)-s-triazine

Downstream raw materials:

6-amino-3-(2,3,5-tri-O-benzoyl-β-D-ribosyl)-1,3,5-triazine-2,4(1H,3H)-dione

6-amino-3-β-D-ribofuranosyl-1,3,5-triazine-2,4(1H,3H)-dione

5-azacytidine

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 28998-36-9 4-Amino-1-(2-O,3-O,5-O-tribenzoyl-β-D-ribofuranosyl)-1,3,5-triazin-2(1H)-one

Send

Send

Metric Ton KG G Pound L ML

Send

Send