N-(Trimethylsilyl)-4-[(trimethylsilyl)oxy]-2-amine-1,3,5-triazin

Base Information

• Chemical Name: N-(Trimethylsilyl)-4-[(trimethylsilyl)oxy]-2-amine-1,3,5-triazin
• CAS No.: 52523-35-0
• Molecular Formula: C9H20N4OSi2
• Molecular Weight: 256.455
• Hs Code.: 2933699090
• Mol file: 52523-35-0.mol

Synonyms:Bis(trimethylsilyl)-5-azacytosine;N-(Trimethylsilyl)-4-[(trimethylsilyl)oxy]-2-amine-1,3,5-triazin

Chemical Property of N-(Trimethylsilyl)-4-[(trimethylsilyl)oxy]-2-amine-1,3,5-triazin

Chemical Property:

• Boiling Point: 306℃
• PKA: 3.24±0.10(Predicted)
• Flash Point: 139℃
• PSA: 61.88000
• Density: 1.025
• LogP: 1.64110

Purity/Quality:

98%Min ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N-(Trimethylsilyl)-4-[(trimethylsilyl)oxy]-2-amine-1,3,5-triazin

There total 5 articles about N-(Trimethylsilyl)-4-[(trimethylsilyl)oxy]-2-amine-1,3,5-triazin which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

5-azacytosine (931-86-2) + 1,1,1,3,3,3-hexamethyl-disilazane (999-97-3) → 2-(trimethylsilylamino)-4-(trimethylsilyloxy)-s-triazine (52523-35-0)

Guidance literature:

With ammonium sulfate; for 8h; Product distribution / selectivity; Reflux;

Reference yield:

5-azacytosine (931-86-2) + chloro-trimethyl-silane (75-77-4) → 2-(trimethylsilylamino)-4-(trimethylsilyloxy)-s-triazine (52523-35-0)

Guidance literature:

With ammonium sulfate; 1,1,1,3,3,3-hexamethyl-disilazane; for 17h; Reflux;

Reference yield:

5-azacytosine (931-86-2) + N,O-bis-(trimethylsilyl)-acetamide (10416-59-8) → 2-(trimethylsilylamino)-4-(trimethylsilyloxy)-s-triazine (52523-35-0)

Guidance literature:

In acetonitrile; at 50 ℃; for 2h; Inert atmosphere;

DOI:10.1016/j.tet.2017.01.043

upstream raw materials:

5-azacytosine

1,1,1,3,3,3-hexamethyl-disilazane

5-azacytosine

chloro-trimethyl-silane

Downstream raw materials:

(2R,5S)- and (2R,5R)-4-amino-1-{2-[[(tert-butyldiphenylsilyl)oxy]methyl]-1,3-oxathiolan-5-yl}-1,2,4-triazine-2(1H)-one

1-(2,3,5-tri-O-benzoyl-β-L-ribofuranosyl)-5-azacytosine

5-azacytidine

1-(3,5-di-O-p-chlorobenzoyl-2-deoxy-β-D-ribofuranosyl)-5-azacytosine