4-(4'-METHOXYBENZENESULFONYLAMINO)BENZOIC ACID

Base Information

• Chemical Name: 4-(4'-METHOXYBENZENESULFONYLAMINO)BENZOIC ACID
• CAS No.: 63421-69-2
• Molecular Formula: C14H13NO5S
• Molecular Weight: 307.32200
• Hs Code.: 2935009090
• Mol file: 63421-69-2.mol

Synonyms:4-(4-METHOXY-BENZENESULFONYLAMINO)-BENZOIC ACID;

Chemical Property of 4-(4'-METHOXYBENZENESULFONYLAMINO)BENZOIC ACID

Chemical Property:

• PSA: 101.08000
• LogP: 3.34800

Purity/Quality:

98%min ^*data from raw suppliers

4-(4''-Methoxybenzenesulfonylamino)benzoicAcid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-(4'-METHOXYBENZENESULFONYLAMINO)BENZOIC ACID

There total 5 articles about 4-(4'-METHOXYBENZENESULFONYLAMINO)BENZOIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

4-amino-benzoic acid (150-13-0,159246-81-8,8014-65-1) + 4-methoxy-phenyl-sulphonyl chloride (98-68-0) → 4-(4-methoxybenzenesulfonylamino)benzoic acid (63421-69-2)

Guidance literature:

With fly-ash:H₃PO₄; In tetrahydrofuran; at 20 ℃; Solvent; Catalytic behavior; Sonication;

DOI:10.4067/s0717-97072019000104386

Reference yield: 92.0%

ethyl 4-((4-methoxyphenyl)sulfonamido)benzoate (89113-19-9) → 4-(4-methoxybenzenesulfonylamino)benzoic acid (63421-69-2)

Guidance literature:

With lithium hydroxide monohydrate; In tetrahydrofuran; water; at 40 ℃; for 16h; Inert atmosphere;

DOI:10.1002/cmdc.202000594

Reference yield:

methyl 4-{[(4-methoxyphenyl)sulfonyl]amino}benzoate (349398-17-0) → 4-(4-methoxybenzenesulfonylamino)benzoic acid (63421-69-2)

Guidance literature:

methyl 4-{[(4-methoxyphenyl)sulfonyl]amino}benzoate; With methanol; lithium hydroxide; In tetrahydrofuran; at 110 ℃; for 0.5h; Microwave irradiation;

With hydrogenchloride; In tetrahydrofuran; methanol; water;

DOI:10.1016/j.bmc.2008.12.020

upstream raw materials:

methyl 4-{[(4-methoxyphenyl)sulfonyl]amino}benzoate

4-methoxycarbonyl aniline

4-amino-benzoic acid

4-methoxy-phenyl-sulphonyl chloride

Downstream raw materials:

4-(4-Methoxy-benzenesulfonylamino)-benzoyl chloride

Refernces

• 1、 Dineshkumar, Selvakumar,Thirunarayanan, Ganesamoorthy. "Bio-potent sulfonamides". . p. 4386 - 4391. Retrieved 2019/06/27.
• 2、 Ayesa, Susana,Lindquist, Charlotta,Agback, Tatiana,Benkestock, Kurt,Classon, Bjoern,Henderson, Ian,Hewitt, Ellen,Jansson, Katarina,Kallin, Anders,Sheppard, Dave,Samuelsson, Bertil. "Solid-phase parallel synthesis and SAR of 4-amidofuran-3-one inhibitors of cathepsin S: Effect of sulfonamides P3 substituents on potency and selectivity". experimental part. p. 1307 - 1324. Retrieved 2009/08/08.