Technology Process of Hexanedinitrile, 2-(3,5-dimethylphenyl)-
There total 1 articles about Hexanedinitrile, 2-(3,5-dimethylphenyl)- which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
4-Chlorobutyronitrile; 3,5-dimethylphenylacetonitrile;
With
sodium ethanolate; Diethyl carbonate;
Heating;
With
potassium hydroxide;
In
ethanol;
for 0.5h;
Further stages.;
Heating;
DOI:10.1039/b303658h
- Guidance literature:
-
With
sodium hydride;
In
1,4-dioxane;
for 2.5h;
Heating;
DOI:10.1039/b303658h
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 93 percent / NaH / dioxane / 2.5 h / Heating
2: 55 percent / glacial acetic acid; aq. HCl / 6 h / Heating
3: 35 percent / 3 h / 55 - 130 °C
4: 90 percent / aq. NH3 / 24 h / Heating
5: 80 percent / N,O-bis(trimethylsilyl)acetamide / CHCl3 / 5 h / 20 °C
With
hydrogenchloride; ammonium hydroxide; N,O-bis-(trimethylsilyl)-acetamide; sodium hydride; acetic acid;
In
1,4-dioxane; chloroform;
1: Thorpe-Ziegler reaction;
DOI:10.1039/b303658h
