Technology Process of 3-(4-heptan-2-yloxy-1H-indol-7-yl)cyclohexan-1-ol
There total 11 articles about 3-(4-heptan-2-yloxy-1H-indol-7-yl)cyclohexan-1-ol which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
tetrabutyl ammonium fluoride;
In
tetrahydrofuran;
for 0.25h;
DOI:10.1021/jm00158a023
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 1.) tert-butyllithium, 2.) copper iodide, tributyl phosphine, 3.) boron trifluoride etherate
2: 82 percent / sodium borohydride / tetrahydrofuran; methanol / -78 - 0 °C
3: 87 percent / tetra-n-butylammonium fluoride / tetrahydrofuran / 0.25 h
With
sodium tetrahydroborate; copper(l) iodide; tributylphosphine; boron trifluoride diethyl etherate; tetrabutyl ammonium fluoride; tert.-butyl lithium;
In
tetrahydrofuran; methanol;
DOI:10.1021/jm00158a023
- Guidance literature:
-
Multi-step reaction with 9 steps
1: 92 percent / K2CO3 / dimethylformamide / 100 °C
2: methanol / 0 - 5 °C
3: xylene / Heating
4: 1 N aq. NaOH / dioxane / Heating
5: 66 percent / copper chromite / quinoline / 1 h / 210 °C
6: 1.) lithium bis(trimethylsilyl)amide / 1.) THF, -78 deg C, 10 min, 2.) THF
7: 1.) tert-butyllithium, 2.) copper iodide, tributyl phosphine, 3.) boron trifluoride etherate
8: 82 percent / sodium borohydride / tetrahydrofuran; methanol / -78 - 0 °C
9: 87 percent / tetra-n-butylammonium fluoride / tetrahydrofuran / 0.25 h
With
sodium hydroxide; sodium tetrahydroborate; copper(l) iodide; copper chromite; tributylphosphine; boron trifluoride diethyl etherate; tetrabutyl ammonium fluoride; tert.-butyl lithium; potassium carbonate; lithium hexamethyldisilazane;
In
tetrahydrofuran; 1,4-dioxane; quinoline; methanol; N,N-dimethyl-formamide; xylene;
DOI:10.1021/jm00158a023