1,3-Pyrazolidinedicarboxylic acid, 2-[(2S)-2-(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)-1-oxo-4-pentenyl]-, 3-methyl 1-(phenylmethyl) ester, (3S)-

Base Information

Chemical Name:1,3-Pyrazolidinedicarboxylic acid, 2-[(2S)-2-(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)-1-oxo-4-pentenyl]-, 3-methyl 1-(phenylmethyl) ester, (3S)-
CAS No.:635291-67-7
Molecular Formula:C26H25N3O7
Molecular Weight:491.5
Hs Code.:

1,3-Pyrazolidinedicarboxylic acid,
2-[(2S)-2-(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)-1-oxo-4-pentenyl]-,
3-methyl 1-(phenylmethyl) ester, (3S)-

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Chemical Property of 1,3-Pyrazolidinedicarboxylic acid, 2-[(2S)-2-(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)-1-oxo-4-pentenyl]-, 3-methyl 1-(phenylmethyl) ester, (3S)-

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Technology Process of 1,3-Pyrazolidinedicarboxylic acid, 2-[(2S)-2-(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)-1-oxo-4-pentenyl]-, 3-methyl 1-(phenylmethyl) ester, (3S)-

There total 4 articles about 1,3-Pyrazolidinedicarboxylic acid, 2-[(2S)-2-(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)-1-oxo-4-pentenyl]-, 3-methyl 1-(phenylmethyl) ester, (3S)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 635291-66-6
3-methyl 1-(phenylmethyl) (3S)-1,3-pyrazolidinedicarboxylate

: 916049-18-8
2-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-pent-4-enoic acid chloride

: 635291-67-7
methyl 2-[2-(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)pent-4-enoyl]-1-benzyloxycarbonylpyrazolidine-3-carboxylate

Guidance literature:: With sodium hydrogencarbonate; In water; toluene; at 20 ℃;
DOI:10.1016/j.tet.2003.09.027

Reference yield:

: 110658-33-8
(S)-2-(1,3-dioxoisoindolin-2-yl)pent-4-enoic acid

: 635291-67-7
methyl 2-[2-(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)pent-4-enoyl]-1-benzyloxycarbonylpyrazolidine-3-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: PCl₅ / diethyl ether / 1 h / 0 °C

2: 130 mg / sodium hydrogen carbonate / toluene; H₂O / 20 °C

With phosphorus pentachloride; sodium hydrogencarbonate; In diethyl ether; water; toluene;
DOI:10.1016/j.tet.2003.09.027

Reference yield:

: 501-53-1,94274-21-2
benzyl chloroformate

: 635291-67-7
methyl 2-[2-(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)pent-4-enoyl]-1-benzyloxycarbonylpyrazolidine-3-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium cyanoborohydride; acetic acid / 1 h / 20 °C

1.2: 29 percent / triethylamine / CH₂Cl₂ / 2 h / 20 °C

2.1: 74 percent / methanol; CH₂Cl₂ / 0 - 20 °C

3.1: 130 mg / sodium hydrogen carbonate / toluene; H₂O / 20 °C

With sodium cyanoborohydride; sodium hydrogencarbonate; acetic acid; In methanol; dichloromethane; water; toluene;
DOI:10.1016/j.tet.2003.09.027