635291-66-6

Upstream product

• 109-88-6 magnesium methanolate 
• 1398752-11-8 phenylmethyl 2-{(1S)-3-iodo-1-[(methyloxy)carbonyl]propyl}hydrazinecarboxylate 
• 1398752-10-7 methyl (2R)-2-hydroxy-4-iodobutanoate 
• 501-53-1 benzyl chloroformate 
• 635291-65-5 (S)-3-((1R,5S,7S)-10,10-Dimethyl-3,3-dioxo-3λ⁶-thia-4-aza-tricyclo[5.2.1.0^1,5]decane-4-carbonyl)-pyrazolidine-1-carboxylic acid benzyl ester 

Downstream Products

• 635291-78-0 (S)-2-[(2S,3S)-2-(1,3-Dioxo-1,3-dihydro-isoindol-2-yl)-5-hydroxy-3-phenyl-pentanoyl]-pyrazolidine-1,3-dicarboxylic acid 1-benzyl ester 3-methyl ester 
• 635291-76-8 methyl (3S)-2-[(2S,3S)-2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-3-phenyl-5-oxopentanoyl]-1-benzyloxycarbonylpyrazolidine-3-carboxylate 
• 635291-67-7 methyl 2-[2-(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)pent-4-enoyl]-1-benzyloxycarbonylpyrazolidine-3-carboxylate 

Relevant academic research and scientific papers

Peptide deformylase inhibitors

The present invention relates to a compound of Formula (I): or a pharmaceutically acceptable salt thereof, corresponding pharmaceutical compositions, compound preparation and treatment methods directed to bacterial infections and inhibition of bacterial peptide deformylase (PDF) activity.

PEPTIDE DEFORMYLASE INHIBITORS

The present invention relates to a compound of Formula (I): or a pharmaceutically acceptable salt thereof, corresponding pharmaceutical compositions, compound preparation and treatment methods directed to bacterial infections and inhi-bition of bacterial peptide deformylase (PDF) activity

TETRAPEPTIDE ANALOGS

Compounds, compositions and methods for treatment of hyperproliferative diseases, such as cancer are provided.

Constrained peptidomimetics: Building bicyclic analogs of pyrazoline derivatives

A synthetic route has been developed for incorporating pyrazoline derivatives as proline surrogates in constrained X-Pro peptidomimetics. The route allows for the synthesis of dipeptide building blocks having either a six or seven-membered-ring annulated