3-(4-Fluorophenyl)-5,6-dihydroimidazo[2,1-b][1,3]thiazole

Base Information

• Chemical Name: 3-(4-Fluorophenyl)-5,6-dihydroimidazo[2,1-b][1,3]thiazole
• CAS No.: 63529-22-6
• Molecular Formula: C₁₁H₉FN₂S
• Molecular Weight: 220.27
• DSSTox Substance ID: DTXSID10351419
• Wikidata: Q82127822
• ChEMBL ID: CHEMBL1619308
• Mol file: 63529-22-6.mol

Synonyms:3-(4-fluorophenyl)-5,6-dihydroimidazo[2,1-b][1,3]thiazole;63529-22-6;3-(4-Fluorophenyl)-5,6-dihydroimidazo[2,1-b]thiazole;Cambridge id 5358994;CHEMBL1619308;DTXSID10351419;Imidazo[2,1-b]thiazole, 3-(4-fluorophenyl)-5,6-dihydro-;STK007044;AKOS000547880;EU-0004849

Chemical Property of 3-(4-Fluorophenyl)-5,6-dihydroimidazo[2,1-b][1,3]thiazole

Chemical Property:

• XLogP3: 1.9
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 1
• Exact Mass: 220.04704763
• Heavy Atom Count: 15
• Complexity: 319

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1CN2C(=CSC2=N1)C3=CC=C(C=C3)F

Technology Process of 3-(4-Fluorophenyl)-5,6-dihydroimidazo[2,1-b][1,3]thiazole

There total 2 articles about 3-(4-Fluorophenyl)-5,6-dihydroimidazo[2,1-b][1,3]thiazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

N,N'-ethylenethiourea (96-45-7) + C21H16FIO3S → 3-(4-fluoro-phenyl)-5,6-dihydro-imidazo[2,1-b]thiazole (63529-22-6)

Guidance literature:

With potassium carbonate; In methanol; for 1h; Heating;

Reference yield:

→ 3-(4-fluoro-phenyl)-5,6-dihydro-imidazo[2,1-b]thiazole (63529-22-6)

Guidance literature:

4-Fluorphenacylbromid, 2-Imidazolidinthiol;

DOI:10.1271/bbb1961.41.543

upstream raw materials:

N,N'-ethylenethiourea