2-AMino-4,4,4-trifluoro-butyric acid ethyl ester

Base Information

• Chemical Name: 2-AMino-4,4,4-trifluoro-butyric acid ethyl ester
• CAS No.: 63664-50-6
• Molecular Formula: C6H10F3NO2
• Molecular Weight: 185.14400
• Mol file: 63664-50-6.mol

Synonyms:2-Amino-4,4,4-trifluoro-butyric acid ethyl ester;2-Amino-4,4,4-trifluor-buttersaeure-aethylester;Ethyl α-amino-β-trifluoromethylpropionate;

Chemical Property of 2-AMino-4,4,4-trifluoro-butyric acid ethyl ester

Chemical Property:

• PSA: 52.32000
• LogP: 1.52950

Purity/Quality:

97% ^*data from raw suppliers

2-Amino-4,4,4-trifluoro-butyricacidethylester 96% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-AMino-4,4,4-trifluoro-butyric acid ethyl ester

There total 3 articles about 2-AMino-4,4,4-trifluoro-butyric acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-azido-4,4,4-trifluoro-butyric acid ethyl ester (63664-47-1) → Ethyl α-amino-β-trifluoromethylpropionate (63664-50-6)

Guidance literature:

With palladium on activated charcoal; ethanol; Hydrogenation;

DOI:10.1021/jo01111a014

Reference yield:

ethyl 2-bromo-4,4,4-trifluorobutanoate (367-33-9) → Ethyl α-amino-β-trifluoromethylpropionate (63664-50-6)

Guidance literature:

Multi-step reaction with 2 steps

1: ethanol; water; sodium azide

2: palladium/charcoal; ethanol / Hydrogenation

With palladium on activated charcoal; sodium azide; ethanol; water;

DOI:10.1021/jo01111a014

Reference yield:

→ Ethyl α-amino-β-trifluoromethylpropionate (63664-50-6)

Guidance literature:

CF3CH2CH(N3)COOEt, H2, 5percent Pd an C, in A.;

upstream raw materials:

2-azido-4,4,4-trifluoro-butyric acid ethyl ester

ethyl 2-bromo-4,4,4-trifluorobutanoate