2-BROMO-4,4,4-TRIFLUOROBUTYRIC ACID ETHYL ESTER

Base Information

• Chemical Name: 2-BROMO-4,4,4-TRIFLUOROBUTYRIC ACID ETHYL ESTER
• CAS No.: 367-33-9
• Molecular Formula: C6H8 Br F3 O2
• Molecular Weight: 249.03
• Hs Code.: 2915900090
• Mol file: 367-33-9.mol

Synonyms:Butyricacid, 2-bromo-4,4,4-trifluoro-, ethyl ester (6CI,8CI)

Chemical Property of 2-BROMO-4,4,4-TRIFLUOROBUTYRIC ACID ETHYL ESTER

Chemical Property:

• Vapor Pressure: 3.18mmHg at 25°C
• Refractive Index: 1.408
• Boiling Point: 154.4°Cat760mmHg
• Flash Point: 47.2°C
• PSA: 26.30000
• Density: 1.546g/cm³
• LogP: 2.26540

Purity/Quality:

98%min ^*data from raw suppliers

2-Bromo-4,4,4-trifluorobutyric acid ethyl ester 97% ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xi

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Ethyl 2-bromo-4,4,4-trifluorobutyrate is used as a pharmaceutical intermediate.

Technology Process of 2-BROMO-4,4,4-TRIFLUOROBUTYRIC ACID ETHYL ESTER

There total 1 articles about 2-BROMO-4,4,4-TRIFLUOROBUTYRIC ACID ETHYL ESTER which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4,4,4-trifluorobutyric acid (406-93-9) → ethyl 2-bromo-4,4,4-trifluorobutanoate (367-33-9)

Guidance literature:

With bromine; phosphorus trichloride; Behandeln des Reaktionsgemisches mit Aethanol;

DOI:10.1021/ja01618a062

Reference yield: 40.0%

2-phenylpyridine (1008-89-5) + ethyl 2-bromo-4,4,4-trifluorobutanoate (367-33-9) → ethyl 4,4,4-trifluoro-2-(3-(pyridin-2-yl)phenyl)butanoate

Guidance literature:

With [ruthenium(II)(η⁶-1-methyl-4-isopropyl-benzene)(chloride)(μ-chloride)]₂; mesitylenecarboxylic acid; potassium carbonate; In 1,4-dioxane; at 120 ℃; for 15h; regioselective reaction; Inert atmosphere; Sealed tube;

DOI:10.1039/c7ob01192j

Reference yield:

ethyl 2-bromo-4,4,4-trifluorobutanoate (367-33-9) + ammonium hydroxide → 3-Amino-4,4,4-trifluorbutyramid (453-32-7)

Guidance literature:

DOI:10.1021/ja01618a062

upstream raw materials:

4,4,4-trifluorobutyric acid

Downstream raw materials:

3-Amino-4,4,4-trifluorbutyramid

Ethyl α-amino-β-trifluoromethylpropionate