Ethanone, 1-(3-pyridazinyl)- (9CI)

Base Information

• Chemical Name: Ethanone, 1-(3-pyridazinyl)- (9CI)
• CAS No.: 1122-63-0
• Molecular Formula: C6H6 N2 O
• Molecular Weight: 122.126
• Hs Code.: 2933990090
• Mol file: 1122-63-0.mol

Synonyms:Ketone,methyl 3-pyridazinyl (7CI,8CI); 3-Acetylpyridazine; NSC 527814

Chemical Property of Ethanone, 1-(3-pyridazinyl)- (9CI)

Chemical Property:

• Vapor Pressure: 0.00273mmHg at 25°C
• Melting Point: 129 °C
• Boiling Point: 285.9oC at 760 mmHg
• PKA: 0.77±0.10(Predicted)
• Flash Point: 131oC
• PSA: 42.85000
• Density: 1.136g/cm3
• LogP: 0.67920
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

98%,99%, ^*data from raw suppliers

1-(Pyridazin-3-yl)ethanone ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Ethanone, 1-(3-pyridazinyl)- (9CI)

There total 4 articles about Ethanone, 1-(3-pyridazinyl)- (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

methyl magnesium iodide (917-64-6) + pyridazine-3-carbonitrile (53896-49-4) → 1-(pyridazin-3-yl)ethan-1-one (1122-63-0)

Guidance literature:

In diethyl ether; benzene; at -15 ℃; for 1.5h;

Reference yield: 45.0%

pyridazine-3-carbonitrile (53896-49-4) + methyllithium (917-54-4) → 1-(pyridazin-3-yl)ethan-1-one (1122-63-0)

Guidance literature:

In tetrahydrofuran; diethyl ether; at -70 ℃; for 0.5h;

Reference yield:

1H-imidazole (288-32-4) + C6H5N2O(1-)*K(1+) → potassium 1H-imidazolide (20671-53-8) + 1-(pyridazin-3-yl)ethan-1-one (1122-63-0)

Guidance literature:

In dimethyl sulfoxide; at 24.9 ℃; Equilibrium constant;

upstream raw materials:

methyl magnesium iodide

pyridazine-3-carbonitrile

methyllithium

1H-imidazole

Downstream raw materials:

1H-imidazole

3-(1-((triisopropylsilyl)oxy)vinyl)pyridazine

2-bromo-1-(pyridazin-3-yl)ethan-1-one

Refernces

• 1、 Easmon,Heinisch,Holzer,Rosenwirth. "Synthesis and antiviral activity of thiosemicarbazone derivatives of pyridazinecarbaldehydes and alkyl pyridazinyl ketones". . p. 1196 - 1201. Retrieved 2007/10/02.