3,6,8-Tribromoimidazo[1,2-a]pyrazine

Base Information

• Chemical Name: 3,6,8-Tribromoimidazo[1,2-a]pyrazine
• CAS No.: 63744-24-1
• Molecular Formula: C6H2Br3N3
• Molecular Weight: 355.814
• Hs Code.: 2933990090
• DSSTox Substance ID: DTXSID70557435
• Wikidata: Q82439329
• Mol file: 63744-24-1.mol

Synonyms:3,6,8-Tribromoimidazo[1,2-a]pyrazine;63744-24-1;3,6,8-Tribromo-imidazo[1,2-a]pyrazine;MFCD11226367;SCHEMBL2179685;DTXSID70557435;KOYWJTGSMJPNFV-UHFFFAOYSA-N;BrC1=CN=C2N1C=C(Br)N=C2Br;AKOS005256703

Chemical Property of 3,6,8-Tribromoimidazo[1,2-a]pyrazine

Chemical Property:

• PKA: -3.31±0.30(Predicted)
• PSA: 30.19000
• Density: 2.73±0.1 g/cm3(Predicted)
• LogP: 3.01680
• Storage Temp.: 2-8°C
• XLogP3: 3.8
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 0
• Exact Mass: 354.77784
• Heavy Atom Count: 12
• Complexity: 179

Purity/Quality:

NLT 98% ^*data from raw suppliers

3,6,8-Tribromo-imidazo[1,2-a]pyrazine 95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=C(N2C=C(N=C(C2=N1)Br)Br)Br

Technology Process of 3,6,8-Tribromoimidazo[1,2-a]pyrazine

There total 3 articles about 3,6,8-Tribromoimidazo[1,2-a]pyrazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

6,8-dibromoimidazo[1,2-a]pyrazine (63744-22-9) → 3,6,8-tribromoimidazo[1,2-a]pyrazine (63744-24-1)

Guidance literature:

With N-Bromosuccinimide; In acetonitrile; at 20 ℃; for 2h;

DOI:10.1039/c5ra00584a

Reference yield:

aqueous Na2 CO3 + 6,8-dibromoimidazo[1,2-a]pyrazine (63744-22-9) → 3,6,8-tribromoimidazo[1,2-a]pyrazine (63744-24-1)

Guidance literature:

With N-Bromosuccinimide; In chloroform;

Reference yield:

→ 3,6,8-tribromoimidazo[1,2-a]pyrazine (63744-24-1)

Guidance literature:

5, NBS;

DOI:10.1021/jo00862a005

upstream raw materials:

6,8-dibromoimidazo[1,2-a]pyrazine

Refernces

• 1、 Bouloc, Nathalie,Large, Jonathan M.,Kosmopoulou, Magda,Sun, Chongbo,Faisal, Amir,Matteucci, Mizio,Reynisson, Jóhannes,Brown, Nathan,Atrash, Butrus,Blagg, Julian,McDonald, Edward,Linardopoulos, Spiros,Bayliss, Richard,Bavetsias, Vassilios. "Structure-based design of imidazo[1,2-a]pyrazine derivatives as selective inhibitors of Aurora-A kinase in cells". scheme or table. p. 5988 - 5993. Retrieved 2010/11/02.
• 2、 -. "Novel imidazopyrazines as cyclin dependent kinase inhibitors". Page/Page column 46. . Retrieved 2008/06/13.