63744-22-9

Basic information

• Product Name: 6,8-DIBROMOIMIDAZO[1,2-A]PYRAZINE
• Synonyms: 6,8-DIBROMOIMIDAZO[1,2-A]PYRAZINE;6,8-Dibromoimidazol[1,2-a]pyrazine;8-dibroMoiMidazo[1;IMidazo[1,2-a]pyrazine, 6,8-dibroMo-
• CAS NO: 63744-22-9
• Molecular Formula: C₆H₃Br₂N₃
• Molecular Weight: 276.92
• EINECS: 1592732-453-0
• Product Categories: Heterocycles series;CHIRAL CHEMICALS;Aromatics;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals
• Mol File: 63744-22-9.mol
• Article Data: 37

Chemical Properties

• Melting Point: 165.0 to 169.0 °C
• Appearance: /
• Density: 2.36 g/cm³
• Refractive Index: 1.802
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: -0.36±0.30(Predicted)
• Water Solubility: Slightly soluble in water.
• CAS DataBase Reference: 6,8-DIBROMOIMIDAZO[1,2-A]PYRAZINE(CAS DataBase Reference)
• NIST Chemistry Reference: 6,8-DIBROMOIMIDAZO[1,2-A]PYRAZINE(63744-22-9)
• EPA Substance Registry System: 6,8-DIBROMOIMIDAZO[1,2-A]PYRAZINE(63744-22-9)

Safety Data

• Hazardous Substances Data: 63744-22-9(Hazardous Substances Data)

Usage

Uses

Different sources of media describe the Uses of 63744-22-9 differently. You can refer to the following data:
1. 6,8-Dibromoimidazo[1,2-a]pyrazine is a imidazopyrazine derivative with uterine-relaxing, antibronchospastic, and cardiac-stimulating properties. 6,8-Dibromoimidazo[1,2-a]pyrazine also displays theophylline-like properties.
2. It is an Intermediate in organic syntheses.

InChI:InChI=1/C6H3Br2N3/c7-4-3-11-2-1-9-6(11)5(8)10-4/h1-3H

Upstream product

• 7252-83-7 1-bromo-2,2-dimethoxyethane 
• 24241-18-7 2-amino-3,5-dibromopyrazine 
• 2032-35-1 Bromoacetaldehyde diethyl acetal 
• 17157-48-1 bromoacetaldehyde 
• 107-20-0 2-chloroethanal 

Downstream Products

• 886854-81-5 4-(6-bromo-imidazo[1,2-a]pyrazin-8-ylamino)-benzoic acid ethyl ester 
• 1021154-34-6 tert-butyl 4-(4-((6-bromoimidazo[1,2-a]pyrazin-8-yl)amino)phenyl)piperazine-1-carboxylate 
• 886855-44-3 4-(6-bromo-imidazo[1,2-a]pyrazin-8-ylamino)-benzonitrile 
• 746654-29-5 6-bromo-8-(4-p-tolyl-imidazol-1-yl)-imidazo[1,2-a]pyrazine 
• 445263-82-1 (6-bromo-imidazo[1,2-a]pyrazin-8-yl)-phenyl-amine 
• 886854-83-7 4-(6-bromo-imidazo[1,2-a]pyrazin-8-ylamino)-benzoic acid 
• 1255097-90-5 C₁₇H₁₈BrN₅O 
• 445263-72-9 6-bromo-N-(4-morpholinophenyl)imidazo[1,2-a]pyrazine-8-amine 
• 1255097-89-2 C₁₉H₁₄BrN₅O 
• 864546-06-5 4-(6-bromo-imidazo[1,2-a]pyrazin-8-ylamino)-cyclohexanol 
• 1255097-87-0 C₁₂H₈BrClN₄ 
• 1255097-86-9 C₁₃H₁₁BrN₄O 
• 1255097-88-1 C₁₄H₁₂BrN₅O 
• 1351373-54-0 N-cyclopropyl-4-{8-[(3-hydroxypropyl)amino]-6-(3-hydroxyprop-1-yn-1-yl)imidazo[1,2-a]pyrazin-3-yl}benzamide 

Relevant articles and documents

Synthesis of new triazole based imidazo[1,2-a]pyrazine-benzimidazole conjugates: H-bonding assisted FRET efficient ratiometric detection of pyrophosphate

Triazole tethered imidazo[1,2-a]pyrazine-benzimidazole conjugates 13-38 has been synthesized by click and Suzuki-Miyaura cross coupling reactions at C-8 and C-6 positions, respectively. The research findings clearly predicted that by modification of electronic structure of the receptor, the sensitivity of the recognition process could be modified. Compound 24 with hydroxyphenyl substituent, showed stronger binding to the pyrophosphate than other compounds. Compound 24 has been used as selective probe for ratiometric detection of pyrophosphate amongst the other anions. The binding event of compound 24 toward PPi has been successfully evaluated by absorption and emission spectroscopy as well as NMR titration method. The compound 24 showed H-bonding assisted facilitation of FRET phenomenon in the presence of PPi.

IMIDAZO[1,2-A]PYRAZINE MODULATORS OF THE ADENOSINE A2A RECEPTOR

The present invention relates to the compound of formula (I) and salts, stereoisomers, tautomers, isotopologues,or N-oxides thereof. The present invention is further concerned with the use of such a compound or salt, stereoisomer, tautomer, isotopologues,or N-oxide thereof as medicament and a pharmaceutical composition comprising said compound.

Method for synthesizing 6,8-dibromo imidazo[1,2a] pyrazine

The invention relates to a method for synthesizing 6,8-dibromo imidazo[1,2a] pyrazine. The method comprises the following steps: by taking 2-amino-3,5-dibromo pyrazine and chloroacetaldehyde as raw materials, in a proper solvent, performing reaction for 4-12 hours at 25-150 DEG C, and purifying, thereby obtaining a purified product, namely, 6,8-dibromo imidazo[1,2a] pyrazine. According to the method, reaction raw materials are easily available, the material price is reasonable, the reaction condition is gentle, the operation is easy, the control is easy, the aftertreatment is simple, the product quality is stable and the purity is high.