1H-Pyrazole-4-carboxylic acid, 5-[[2,2-dicyano-1-(phenylamino)ethenyl]amino]-1-(1,2-dihydro-1-methyl- 2-oxo-4-quinolinyl)-3-(methylthio)-, ethyl ester

Base Information

Chemical Name:1H-Pyrazole-4-carboxylic acid, 5-[[2,2-dicyano-1-(phenylamino)ethenyl]amino]-1-(1,2-dihydro-1-methyl- 2-oxo-4-quinolinyl)-3-(methylthio)-, ethyl ester
CAS No.:637757-26-7
Molecular Formula:C27H23N7O3S
Molecular Weight:525.591
Hs Code.:

1H-Pyrazole-4-carboxylic acid,
5-[[2,2-dicyano-1-(phenylamino)ethenyl]amino]-1-(1,2-dihydro-1-methyl-
2-oxo-4-quinolinyl)-3-(methylthio)-, ethyl ester

Synonyms:

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Chemical Property of 1H-Pyrazole-4-carboxylic acid, 5-[[2,2-dicyano-1-(phenylamino)ethenyl]amino]-1-(1,2-dihydro-1-methyl- 2-oxo-4-quinolinyl)-3-(methylthio)-, ethyl ester

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Technology Process of 1H-Pyrazole-4-carboxylic acid, 5-[[2,2-dicyano-1-(phenylamino)ethenyl]amino]-1-(1,2-dihydro-1-methyl- 2-oxo-4-quinolinyl)-3-(methylthio)-, ethyl ester

There total 3 articles about 1H-Pyrazole-4-carboxylic acid, 5-[[2,2-dicyano-1-(phenylamino)ethenyl]amino]-1-(1,2-dihydro-1-methyl- 2-oxo-4-quinolinyl)-3-(methylthio)-, ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

: 103-72-0
phenyl isothiocyanate

: 109-77-3
malononitrile

: 637757-08-5
ethyl 5-amino-1-(1-methyl-2-oxo-1,2-dihydroquinolin-4-yl)-3-methylsulfanyl-1H-pyrazole-4-carboxylate

: 637757-26-7
ethyl 5-[1-anilino-2,2-dicyano(vinylamino)]-1-(1-methyl-2-oxo-1,2-dihydroquinolin-4-yl)-3-methylsulfanyl-1H-pyrazole-4-carboxylate

Guidance literature:: phenyl isothiocyanate; malononitrile; With tetrabutylammomium bromide; potassium carbonate; In 1,4-dioxane; at 60 ℃;

ethyl 5-amino-1-(1-methyl-2-oxo-1,2-dihydroquinolin-4-yl)-3-methylsulfanyl-1H-pyrazole-4-carboxylate; In 1,4-dioxane;
DOI:10.1080/10426500307880

Reference yield:

: 17823-58-4
ethyl 2-cyano-3,3-di(methylsulfanyl)acrylate

: 637757-26-7
ethyl 5-[1-anilino-2,2-dicyano(vinylamino)]-1-(1-methyl-2-oxo-1,2-dihydroquinolin-4-yl)-3-methylsulfanyl-1H-pyrazole-4-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1.1: 85 percent / dimethylformamide / 1 h / Heating

2.1: K₂CO₃; tetrabutylammonium bromide / dioxane / 60 °C

2.2: 55 percent / dioxane

With tetrabutylammomium bromide; potassium carbonate; In 1,4-dioxane; N,N-dimethyl-formamide;
DOI:10.1080/10426500307880

Reference yield:

: 192633-21-9
4-hydrazino-1-methyl-2(1H)-quinolinone

: 637757-26-7
ethyl 5-[1-anilino-2,2-dicyano(vinylamino)]-1-(1-methyl-2-oxo-1,2-dihydroquinolin-4-yl)-3-methylsulfanyl-1H-pyrazole-4-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1.1: 85 percent / dimethylformamide / 1 h / Heating

2.1: K₂CO₃; tetrabutylammonium bromide / dioxane / 60 °C

2.2: 55 percent / dioxane

With tetrabutylammomium bromide; potassium carbonate; In 1,4-dioxane; N,N-dimethyl-formamide;
DOI:10.1080/10426500307880