17823-58-4Relevant articles and documents
Design and synthesis of potent N-phenylpyrimidine derivatives for the treatment of skin cancer
Chaube, Udit J.,Vyas, Vivek K.,Bhatt, Hardik G.
, p. 10285 - 10297 (2016)
The development of novel synthetic compounds for the treatment of skin cancer is much needed, as there is a sudden rise in the incidence of skin cancer throughout the world and the available chemotherapy is facing problems of resistance. Hence, present re
Synthesis and bioactivity of 2-cyanoacrylates containing a trifluoromethylphenyl moiety
Song, Baoan,Yang, Song,Zhong, Huimin,Jin, Linhong,Hu, Deyu,Liu, Gang
, p. 87 - 92 (2005)
A series of 2-cyanoacrylates containing a trifluoromethylphenyl moiety were synthesized in three steps: ethyl 2-cyano-3,3-dimethylthioacrylate was prepared from ethyl cyanoacetate with carbon disulfide and dimethyl sulfate, then its reaction with 4-trifluoromethylaniline yielded ethyl 2-cyano-3-(4- trifluoromethylphenylamino)-3-methylthioacrylate, and then reacted with an alkylamine. The new structures were verified by elemental analysis, IR, 1H NMR and mass spectra. In the MTT test, these new compounds were found to possess high antitumor activities against PC3 and A431 cells.
Ketene aminal-based lactam derivatives as a novel class of orally active FXa inhibitors
Shi, Yan,Zhang, Jing,Stein, Philip D.,Shi, Mengxiao,O'Connor, Stephen P.,Bisaha, Sharon N.,Li, Chi,Atwal, Karnail S.,Bisacchi, Gregory S.,Sitkoff, Doree,Pudzianowski, Andrew T.,Liu, Eddie C.,Hartl, Karen S.,Seiler, Steven M.,Youssef, Sonia,Steinbacher, Thomas E.,Schumacher, William A.,Rendina, Alan R.,Bozarth, Jeffrey M.,Peterson, Tara L.,Zhang, Ge,Zahler, Robert
, p. 5453 - 5458 (2005)
N,N′-Disubstituted ketene aminals are good bioisosteres of thiourea functional groups. We report the design and synthesis of a novel class of ketene aminal-based lactam derivatives as potent and orally active FXa inhibitors.
Synthesis, antiviral and antifungal bioactivity of 2-cyano-acrylate derivatives containing phosphonyl moieties
Lv, Yin-Pu,Wang, Xian-You,Song, Bao-An,Yang, Song,Yan, Kai,Xu, Guang-Fang,Bhadury, Pinaki S.,Liu, Fang,Jin, Lin-Hong,Hu, De-Yu
, p. 965 - 978 (2007)
Alkyl 2-cyano-3-methylthio-3-phosphonylacrylates were synthesized by the reaction of alkyl 2-cyano-3,3-dimethylthioacrylates with dialkyl phosphites. The structures of the new compounds were characterized by elemental analyses, IR, 1H-, 13
Synthesis, spectral characterization and photophysical studies of tetrahydroquinolines
Kennedy, L. John,Singh, Fateh V.,Subashini, C.
, (2020/10/18)
A metal-free, ultrasound-assisted, fast synthesis of fluorescent N-Boc-protected 1,2,3,4–tetrahydroquinolines 9a-p is described through carbanion-induced ring transformation of 6-aryl-2H-pyran-2-ones 7 with tert?butyl 3-oxopiperidine-1-carboxylate 8 under
Tailored-design Synthesis of Sulfapyrimidine Derivatives
Azzam, Rasha A.
, p. 619 - 627 (2019/01/04)
In this paper, we report an efficient and convenient approach for the synthesis of tailored-design target sulfapyrimidine derivatives expected to show remarkable antimicrobial activities. The approach is based on reacting arylsulfonyl guanidine with α,β-unsaturated carbonyl compounds to afford N-(4,6-diarylpyrimidin-2-yl)arylsulfonamide or with ylidene derivatives to afford N-(6-aryl-5-cyanopyrimidin-2-yl)arylsulfonamide, N-(4-amino-5-cyano-6-(methylthio)-pyrimidin-2-yl)-arylsulfonamide, and N-(5-cyanopyrimidin-2-yl)arylsulfonamide compounds through Michael addition reaction. The structure of the newly synthesized compounds was confirmed from spectral data and elemental analysis.