17823-58-4Relevant academic research and scientific papers
Design and synthesis of potent N-phenylpyrimidine derivatives for the treatment of skin cancer
Chaube, Udit J.,Vyas, Vivek K.,Bhatt, Hardik G.
, p. 10285 - 10297 (2016)
The development of novel synthetic compounds for the treatment of skin cancer is much needed, as there is a sudden rise in the incidence of skin cancer throughout the world and the available chemotherapy is facing problems of resistance. Hence, present re
Bacterial cell leakage potential of newly synthesized quinazoline derivatives of 1,5-benzodiazepines analogue
Dwivedi, Jaya,Kishore, Dharma,Misra, Apoorva,Sharma, Swapnil,Shukla, Shruti
, (2020)
Novel quinazoline embellished analogues of 1,5-benzodiazepine (6, 9, 13, 17, 21 and 24) were synthesized using one-pot domino approach. Structure of the compounds synthesized, were established with the help of IR, 1H NMR, 13C NMR and
Synthesis and bioactivity of 2-cyanoacrylates containing a trifluoromethylphenyl moiety
Song, Baoan,Yang, Song,Zhong, Huimin,Jin, Linhong,Hu, Deyu,Liu, Gang
, p. 87 - 92 (2005)
A series of 2-cyanoacrylates containing a trifluoromethylphenyl moiety were synthesized in three steps: ethyl 2-cyano-3,3-dimethylthioacrylate was prepared from ethyl cyanoacetate with carbon disulfide and dimethyl sulfate, then its reaction with 4-trifluoromethylaniline yielded ethyl 2-cyano-3-(4- trifluoromethylphenylamino)-3-methylthioacrylate, and then reacted with an alkylamine. The new structures were verified by elemental analysis, IR, 1H NMR and mass spectra. In the MTT test, these new compounds were found to possess high antitumor activities against PC3 and A431 cells.
Synthesis and biological evaluation of some 5-ethoxycarbonyl-6-isopropylamino-4-(substitutedphenyl)aminopyrimidines as potent analgesic and anti-inflammatory agents
Chhabria, Mahesh T.,Bhatt, Hardik G.,Raval, Hitesh G.,Oza, Pratik M.
, p. 1022 - 1024 (2007)
Synthesis and biological evaluation of some 5-ethoxycarbonyl-6-isopropylamino-4-(substitutedphenyl)aminopyrimidines have been achieved by cyclization of N-[2-ethoxycarbonyl-2-cyano-1-(isopropylamino)vinyl] formamidine in presence of dry HCl in dioxane fol
Ketene aminal-based lactam derivatives as a novel class of orally active FXa inhibitors
Shi, Yan,Zhang, Jing,Stein, Philip D.,Shi, Mengxiao,O'Connor, Stephen P.,Bisaha, Sharon N.,Li, Chi,Atwal, Karnail S.,Bisacchi, Gregory S.,Sitkoff, Doree,Pudzianowski, Andrew T.,Liu, Eddie C.,Hartl, Karen S.,Seiler, Steven M.,Youssef, Sonia,Steinbacher, Thomas E.,Schumacher, William A.,Rendina, Alan R.,Bozarth, Jeffrey M.,Peterson, Tara L.,Zhang, Ge,Zahler, Robert
, p. 5453 - 5458 (2005)
N,N′-Disubstituted ketene aminals are good bioisosteres of thiourea functional groups. We report the design and synthesis of a novel class of ketene aminal-based lactam derivatives as potent and orally active FXa inhibitors.
A sensitive and highly selective fluorescent sensor for In3+
Wu, Yan-Chao,Li, Hui-Jing,Yang, Hua-Zheng
, p. 3394 - 3397 (2010)
A simple neutral fluorescent sensor based on pyrazolo[1,5-a]pyrimidine exhibited a unique selectivity for indium(iii) ion (In3+) over various other metal ions with dramatic fluorescence response in acetonitrile. The Royal Society of Chemistry 2
Synthesis, antiviral and antifungal bioactivity of 2-cyano-acrylate derivatives containing phosphonyl moieties
Lv, Yin-Pu,Wang, Xian-You,Song, Bao-An,Yang, Song,Yan, Kai,Xu, Guang-Fang,Bhadury, Pinaki S.,Liu, Fang,Jin, Lin-Hong,Hu, De-Yu
, p. 965 - 978 (2007)
Alkyl 2-cyano-3-methylthio-3-phosphonylacrylates were synthesized by the reaction of alkyl 2-cyano-3,3-dimethylthioacrylates with dialkyl phosphites. The structures of the new compounds were characterized by elemental analyses, IR, 1H-, 13
A Metal-Free Approach for the Synthesis of 2-Tetralones via Carbanion-Induced Ring Transformation of 2 H -Pyran-2-ones
Shetgaonkar, Samata E.,Singh, Fateh V.
, p. 3540 - 3548 (2018)
A metal-free, ultrasound-assisted approach for the synthesis of highly functionalized 2-tetralones in high yields is described. The process involves ring transformation of 2 H -pyran-2-ones with the spirocyclic ketone 1,4-cyclohexandione monoethylene keta
Synthesis, spectral characterization and photophysical studies of tetrahydroquinolines
Kennedy, L. John,Singh, Fateh V.,Subashini, C.
, (2020/10/18)
A metal-free, ultrasound-assisted, fast synthesis of fluorescent N-Boc-protected 1,2,3,4–tetrahydroquinolines 9a-p is described through carbanion-induced ring transformation of 6-aryl-2H-pyran-2-ones 7 with tert?butyl 3-oxopiperidine-1-carboxylate 8 under
Design, synthesis and biological evaluation of novel DPP-IV inhibitors
Karelia, Chirag,Parmar, Kailash,Teli, Divya,Chhabria, Mahesh
, p. 1227 - 1235 (2020/12/04)
Diabetes mellitus is one of the top ten leading causes of death worldwide. DPP-IV inhibition became an attractive target in controlling type 2 diabetes. Because of the several adverse effects associated with current DPP-IV inhibitors, the discovery and de
