Chemical Property of 3-Aminobenzamide
Chemical Property:
- Appearance/Colour:beige powder
- Vapor Pressure:0.000175mmHg at 25°C
- Melting Point:115-116 °C(lit.)
- Refractive Index:1.632
- Boiling Point:329.6 °C at 760 mmHg
- PKA:16.26±0.50(Predicted)
- Flash Point:153.2 °C
- PSA：69.11000
- Density:1.233 g/cm3
- LogP:1.64920
- Storage Temp.:Store under inert gas
- Sensitive.:Light Sensitive
- Solubility.:ethanol: 50 mg/mL, clear, faintly yellow
- Water Solubility.:Soluble in dimethylformamide (~30 mg/ml), dimethyl sulfoxide (~30 mg/ml), phosphate buffered saline (pH7.2) (~2 mg/ml), water (2
- XLogP3:-0.5
- Hydrogen Bond Donor Count:2
- Hydrogen Bond Acceptor Count:2
- Rotatable Bond Count:1
- Exact Mass:136.063662883
- Heavy Atom Count:10
- Complexity:136
- Purity/Quality:
-
97% *data from raw suppliers
3-Aminobenzamide *data from reagent suppliers
Safty Information:
- Pictogram(s):
Xi
- Hazard Codes:Xi
- Statements:
36/37/38
- Safety Statements:
26-36-37/39
- MSDS Files:
-
SDS file from LookChem
Total 1 MSDS from other Authors
Useful:
- Canonical SMILES:C1=CC(=CC(=C1)N)C(=O)N
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Description
The poly(ADP-ribose) polymerases (PARPs) comprise a family of enzymes which post-translationally modify proteins by poly(ADP-ribosyl)ation. Since some PARPs are activated by DNA strand breaks, PARP signaling has roles in DNA repair, apoptosis, inflammation, and other cellular responses. 3-amino Benzamide is an inhibitor of PARPs (Ki = 1.8 μM). Through its effects on PARPs, 3-amino benzamide causes telomere shortening and stimulates angiogenesis. It has PARP-mediated actions in such diverse diseases as atherosclerosis, neurogenesis, and cancer.
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Uses
The poly(ADP-ribose) polymerases (PARPs) comprise a family of enzymes which post-translationally modify proteins by poly(ADP-ribosyl)ation. Since some PARPs are activated by DNA strand breaks, PARP signaling has roles in DNA repair, apoptosis, inflammation, and other cellular responses. 3-amino Benzamide is an inhibitor of PARPs (Ki = 1.8 μM). Through its effects on PARPs, 3-amino benzamide causes telomere shortening and stimulates angiogenesis. It has PARP-mediated actions in such diverse diseases as atherosclerosis, neurogenesis, and cancer. 3-Aminobenzamide is used as an endogenous poly-ADP-ribosyltransferase inhibitor. Through its effects on PARPs, 3-amino benzamide causes telomere shortening and stimulates angiogenesis. It displays neuroprotective, anti-necrotic effects.
