Ethanesulfonic acid, 1,1,2,2-tetrafluoro-2-(1,1,2,2-tetrafluoroethoxy)-, 4-chloro-2-(diethoxyphosphinyl)phenyl ester

Base Information

• Chemical Name: Ethanesulfonic acid, 1,1,2,2-tetrafluoro-2-(1,1,2,2-tetrafluoroethoxy)-, 4-chloro-2-(diethoxyphosphinyl)phenyl ester
• CAS No.: 639516-89-5
• Molecular Formula: C14H14ClF8O7PS
• Molecular Weight: 544.741
• Mol file: 639516-89-5.mol

Synonyms:

Chemical Property of Ethanesulfonic acid, 1,1,2,2-tetrafluoro-2-(1,1,2,2-tetrafluoroethoxy)-, 4-chloro-2-(diethoxyphosphinyl)phenyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Ethanesulfonic acid, 1,1,2,2-tetrafluoro-2-(1,1,2,2-tetrafluoroethoxy)-, 4-chloro-2-(diethoxyphosphinyl)phenyl ester

There total 1 articles about Ethanesulfonic acid, 1,1,2,2-tetrafluoro-2-(1,1,2,2-tetrafluoroethoxy)-, 4-chloro-2-(diethoxyphosphinyl)phenyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

diethyl 5-chloro-2-hydroxyphenyl phosphonate (83110-00-3) + 5-hydro-3-oxaoctafluoropentanesulfonyl fluoride (104729-49-9) → 4-chloro-2-(diethoxyphosphonyl)phenyl 1,1,2,2-tetra-fluoro-2-(1,1,2,2-tetrafluoroethoxy)ethanesulfonate (639516-89-5)

Guidance literature:

With triethylamine; at 20 ℃; for 8h;

DOI:10.1021/ja038627f DOI:10.1002/hc.20156

Reference yield: 83.0%

1-ethyl-4-ethynylbenzene (40307-11-7) + 4-chloro-2-(diethoxyphosphonyl)phenyl 1,1,2,2-tetra-fluoro-2-(1,1,2,2-tetrafluoroethoxy)ethanesulfonate (639516-89-5) → [5-chloro-2-(4-ethyl-phenylethynyl)-phenyl]-phosphonic acid diethyl ester (639516-96-4)

Guidance literature:

With bis-triphenylphosphine-palladium(II) chloride; triethylamine; In N,N-dimethyl-formamide; at 80 ℃; for 5h;

DOI:10.1021/ja038627f

Reference yield: 81.0%

phenylacetylene (536-74-3) + 4-chloro-2-(diethoxyphosphonyl)phenyl 1,1,2,2-tetra-fluoro-2-(1,1,2,2-tetrafluoroethoxy)ethanesulfonate (639516-89-5) → (5-chloro-2-phenylethynyl-phenyl)-phosphonic acid diethyl ester (639516-95-3)

Guidance literature:

With bis-triphenylphosphine-palladium(II) chloride; triethylamine; In N,N-dimethyl-formamide; at 80 ℃; for 5h;

DOI:10.1021/ja038627f

upstream raw materials:

diethyl 5-chloro-2-hydroxyphenyl phosphonate

5-hydro-3-oxaoctafluoropentanesulfonyl fluoride

Downstream raw materials:

(5-chloro-2-cyclopropylethynyl-phenyl)-phosphonic acid diethyl ester

[5-chloro-2-(4-nitro-phenylethynyl)-phenyl]phosphonic acid diethyl ester

[5-chloro-2-(4-ethyl-phenylethynyl)-phenyl]-phosphonic acid diethyl ester

[5-chloro-2-(3-hydroxy-prop-1-ynyl)-phenyl]-phosphonic acid diethyl ester