(1R,3S)-1,3-Bis(acetylamino)cyclohexane

Base Information

• Chemical Name: (1R,3S)-1,3-Bis(acetylamino)cyclohexane
• CAS No.: 32189-20-1
• Molecular Formula: C₁₀H₁₈N₂O₂
• Molecular Weight: 198.265
• Hs Code.: 2924299090
• Mol file: 32189-20-1.mol

Synonyms:Acetamide,N,N'-1,3-cyclohexanediylbis-, cis-; Acetamide, N,N'-1,3-cyclohexylenebis-, cis-(8CI); NSC 54134; cis-N,N'-Diacetylcyclohexane-1,3-diamine

Chemical Property of (1R,3S)-1,3-Bis(acetylamino)cyclohexane

Chemical Property:

• Boiling Point: 469.1°Cat760mmHg
• Flash Point: 205.3°C
• PSA: 58.20000
• Density: 1.06g/cm³
• LogP: 1.35160

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (1R,3S)-1,3-Bis(acetylamino)cyclohexane

There total 8 articles about (1R,3S)-1,3-Bis(acetylamino)cyclohexane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 6.0%

1,3-diaminocyclohexane (3385-21-5,26772-34-9,26883-70-5,115092-57-4) + acetic anhydride (108-24-7) → cis-N,N'-bis(acetyl)cyclohexane-1,3-diamine (32189-20-1) + trans-N,N'-bis(acetyl)cyclohexane-1,3-diamine (32189-20-1,32189-21-2,32266-56-1)

Guidance literature:

In pyridine; for 2h;

DOI:10.1071/CH02099

Reference yield: 6.0%

1,3-diaminocyclohexane (3385-21-5,26772-34-9,26883-70-5,115092-57-4) + acetic anhydride (108-24-7) → cis-N,N'-bis(acetyl)cyclohexane-1,3-diamine (32189-20-1) + trans-N,N'-bis(acetyl)cyclohexane-1,3-diamine (32189-20-1,32189-21-2,32266-56-1)

Guidance literature:

In pyridine; for 2h;

DOI:10.1071/CH02099

Reference yield:

1,3-diaminocyclohexane (3385-21-5,26772-34-9,26883-70-5,115092-57-4) + ethyl acetate (141-78-6) → C8H16N2O (1016495-70-7) + (1S,3S)-cyclohexane-1,3-diamine (860351-60-6) + trans-1,3-cyclohexanediamine (3385-21-5,26772-34-9,26883-70-5,115092-57-4) + trans-1,3-Diacetamido-cyclohexan (32189-20-1,32189-21-2,32266-56-1)

Guidance literature:

With novozyme 435; In toluene; at 40 ℃; for 5h; Title compound not separated from byproducts.;

DOI:10.1016/j.bmcl.2007.05.034

upstream raw materials:

1,3-diaminocyclohexane

acetic anhydride

cyclohexane-1,3-dicarboxylic acid

ethyl acetate

Downstream raw materials:

(1R,3S)-cyclohexane-1,3-diamine

trans-cyclohexane-1,3-diamine