L-Serine, N-(1-oxohexadecyl)-, tetradecyl ester

Base Information

• Chemical Name: L-Serine, N-(1-oxohexadecyl)-, tetradecyl ester
• CAS No.: 156042-32-9
• Molecular Formula: C₃₃H₆₅NO₄
• Molecular Weight: 539.883
• Mol file: 156042-32-9.mol

Synonyms:Ceramide A2

Chemical Property of L-Serine, N-(1-oxohexadecyl)-, tetradecyl ester

Chemical Property:

• Boiling Point: 655.8±40.0 °C(Predicted)
• PKA: 13.86±0.10(Predicted)
• PSA: 79.12000
• Density: 0.929
• LogP: 10.02940

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of L-Serine, N-(1-oxohexadecyl)-, tetradecyl ester

There total 3 articles about L-Serine, N-(1-oxohexadecyl)-, tetradecyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.5%

N-palmitoyl-O-benzyl-L-serine tetradecyl ester → N-palmitoyl-L-serine tetradecyl ester (156042-32-9)

Guidance literature:

With palladium on activated charcoal; hydrogen; In methanol; at 20 ℃; for 15h; under 15001.5 - 22502.3 Torr; Reagent/catalyst; Temperature;

Reference yield:

N-hexadecanoyl-L-serine methyl ester (114134-57-5,126531-82-6,79876-27-0) → N-palmitoyl-L-serine tetradecyl ester (156042-32-9)

Guidance literature:

Multi-step reaction with 3 steps

1.1: sodium hydride / tetrahydrofuran / 0.5 h / 20 °C / Inert atmosphere

1.2: 20 °C / Inert atmosphere

1.3: 20 °C

2.1: oxalyl dichloride / dichloromethane / 20 °C

2.2: 20 °C / Inert atmosphere

3.1: palladium on activated charcoal; hydrogen / methanol / 15 h / 20 °C / 15001.5 - 22502.3 Torr

With oxalyl dichloride; palladium on activated charcoal; hydrogen; sodium hydride; In tetrahydrofuran; methanol; dichloromethane;

Reference yield:

n-hexadecanoyl chloride (112-67-4) → N-palmitoyl-L-serine tetradecyl ester (156042-32-9)

Guidance literature:

Multi-step reaction with 4 steps

1.1: triethylamine / tetrahydrofuran / 20 °C

2.1: sodium hydride / tetrahydrofuran / 0.5 h / 20 °C / Inert atmosphere

2.2: 20 °C / Inert atmosphere

2.3: 20 °C

3.1: oxalyl dichloride / dichloromethane / 20 °C

3.2: 20 °C / Inert atmosphere

4.1: palladium on activated charcoal; hydrogen / methanol / 15 h / 20 °C / 15001.5 - 22502.3 Torr

With oxalyl dichloride; palladium on activated charcoal; hydrogen; sodium hydride; triethylamine; In tetrahydrofuran; methanol; dichloromethane;

upstream raw materials:

N-hexadecanoyl-L-serine methyl ester

n-hexadecanoyl chloride

Refernces