Palmitoyl chloride

Base Information

• Chemical Name: Palmitoyl chloride
• CAS No.: 112-67-4
• Deprecated CAS: 902459-02-3
• Molecular Formula: C16H31ClO
• Molecular Weight: 274.875
• Hs Code.: 2915 90 70
• European Community (EC) Number: 203-996-7
• NSC Number: 9854
• UN Number: 1760
• UNII: 7642R2JOSB
• DSSTox Substance ID: DTXSID4051582
• Nikkaji Number: J110.173K
• Wikidata: Q27266453
• Mol file: 112-67-4.mol

Synonyms:palmitoyl chloride

Chemical Property of Palmitoyl chloride

Chemical Property:

• Appearance/Colour: clear liquid
• Melting Point: 11-13 °C(lit.)
• Refractive Index: n20/D 1.452(lit.)
• Boiling Point: 323.492 °C at 760 mmHg
• Flash Point: 155.505 °C
• PSA: 17.07000
• Density: 0.913 g/cm³
• LogP: 6.23310
• Storage Temp.: −20°C
• Sensitive.: Moisture Sensitive
• Solubility.: Chloroform (Sparingly), Ethyl Acetate (Slightly)
• Water Solubility.: Decomposition
• XLogP3: 7.3
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 14
• Exact Mass: 274.2063433
• Heavy Atom Count: 18
• Complexity: 180
• Transport DOT Label: Corrosive

Purity/Quality:

98%, ^*data from raw suppliers

Palmitoyl Chloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s): C
• Hazard Codes: C
• Statements: 14-34-29
• Safety Statements: 26-36/37/39-43-45-8

MSDS Files:

SDS file from LookChem

Useful:

• Chemical Classes: Toxic Gases & Vapors -> Other Toxic Gases & Vapors
• Canonical SMILES: CCCCCCCCCCCCCCCC(=O)Cl
• Uses: Palmitoyl Chloride was used as a polymeric carriers for plasmid DNA (pDNA) delivery to 293T cells. A compound which has been used as a polymeric carrier for plasmid DNA delivery to 293T cells Palmitoyl chloride is a compound which has been used as a polymeric carrier for plasmid DNA delivery to 293T cells.

Technology Process of Palmitoyl chloride

There total 10 articles about Palmitoyl chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

1-hexadecylcarboxylic acid (57-10-3) → n-hexadecanoyl chloride (112-67-4)

Guidance literature:

With thionyl chloride; Reflux;

Reference yield: 73.0%

→ 1-(α-Cyclopropylcarbonyl-2-fluorobenzyl)-4-palmitoylthiopiperidine (204204-86-4) + n-hexadecanoyl chloride (112-67-4)

Guidance literature:

Reference yield: 34.7%

→ 1-(2-Fluoro-α-methoxycarbonylbenzyl)-4-palmitoylthiopiperidine (204204-90-0) + n-hexadecanoyl chloride (112-67-4)

Guidance literature:

upstream raw materials:

1-hexadecylcarboxylic acid

hexadecanoic acid methyl ester

sodium palmitate

oxalyl dichloride

Downstream raw materials:

2-palmitoyloxy-1,3-bis-trityloxy-propane

N′-hexadecanoylisonicotinohydrazide

4-hexadecanoyl-2-phenyl-4H-oxazol-5-one

hexadecanoic acid, glycidyl ester

Refernces

• 1、 Liu, Yi,Fan, You,Liu, Xun-Yong,Jiang, Song-Zi,Yuan, Yuan,Chen, Yu,Cheng, Fa,Jiang, Shi-Chun. "Amphiphilic hyperbranched copolymers bearing a hyperbranched core and dendritic shell: Synthesis, characterization and guest encapsulation performance". . p. 8361 - 8369. Retrieved 2012.
• 2、 Lafleche, Fabrice,Durand, Dominique,Nicolai, Taco. "Association of adhesive spheres formed by hydrophobically end-capped PEO. 1. Influence of the presence of single end-capped PEO". . p. 1331 - 1340. Retrieved 2003.
• 3、 Dauben, William G.,Bridon, Dominique P.,Kowalczyk, Bruce A.. "Sonication-Induced Halogenative Decarboxylation of Thiohydroxamic Esters". . p. 6101 - 6106. Retrieved 1989.
• 4、 Ko, Eun Jung,Williams, Craig M.,Savage, G. Paul,Tsanaktsidis, John. "Reducing the cost, smell, and toxicity of the Barton reductive decarboxylation: Chloroform as the hydrogen atom source". . p. 1944 - 1947. Retrieved 2011.
• 5、 Foglia,T.A. et al.. "-". . p. 3452 - 3455. Retrieved 1976.
• 6、 -. "LIPID PRODRUGS OF NEUROSTEROIDS". Paragraph 00324-00325. . Retrieved 2021/08/13.
• 7、 -. "A METHOD FOR MODIFICATION OF PEPTIDES IMMOBILIZED ON A SOLID SUPPORT BY TRACELESS REDUCTIVELY CLEAVABLE LINKER MOLECULES". Page/Page column 57. . Retrieved 2021/02/12.