R162

Base Information

Chemical Name:R162
CAS No.:64302-87-0
Molecular Formula:C17H12O3
Molecular Weight:264.27500
Hs Code.:

Synonyms:2-allyl-1-hydroxyanthracene-9,10-dione;2-Allyl-1-hydroxyanthrachinon;2-Allyl-1-hydroxy-anthraquinone;2-allyl-1-hydroxy-9,10-anthraquinone;1-hydroxy-2-(prop-2'-enyl)anthraquinone;

Suppliers and Price of R162

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

DC Chemicals
R162 >98%
250 mg
$ 1000.00

DC Chemicals
R162 >98%
100 mg
$ 500.00

Total 9 raw suppliers

Chemical Property of R162

Chemical Property:

Melting Point:120 - 120.5 °C (acetone)
Boiling Point:459.0±34.0 °C(Predicted)
PKA:7.43±0.20(Predicted)
PSA：54.37000
Density:1.308±0.06 g/cm3(Predicted)
LogP:2.89610
Storage Temp.:-20°C
Solubility.:Soluble in DMSO (up to 10 mg/ml or in Ethanol (up to 5 mg/ml)

Purity/Quality:

97% ^*data from raw suppliers

R162 >98% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Description R162 (64302-87-0) is a selective inhibitor of glutamate dehydrogenase 1 (GDH1), a commonly upregulated enzyme in human cancers (Ki?= 28.6 μM).? It does not inhibit the activity of other NADPH enzymes such as 6-phosphogluconate dehydrogenase and fumarate hydratase. R162 treatment leads to decreased fumarate levels, lower glutathione peroxidase activity, increased ROS levels and reduced cell proliferation in H1299 and MDA-MB231 cells.? R162 sensitizes LKB-1 deficient tumor cells to anoikis induction.? R162 treatment (at 20 mg/kg/day) significantly attenuates metastatic potential in a xenograft mouse model.2? GDH1 is a promising antimetastasis target and R162 is a useful tool for proof of principal studies.
Uses R162 is a glutamate dehydrogenase 1 inhibitor for the treatment of cancer. A useful bioactive chemical compound.

Technology Process of R162

There total 6 articles about R162 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 64302-83-6
1-(prop-2'-enyloxy)anthraquinone

: 64302-87-0
1-hydroxy-2-(prop-2'-enyl)-9,10-anthraquinone

Guidance literature:: With sodium dithionite; In methanol; N,N-dimethyl-formamide; for 0.583333h; gentle heating effect;
DOI:10.1016/S0040-4039(00)85614-2

Reference yield:

: 129-43-1
1-hydroxyanthraquinone

: 64302-87-0
1-hydroxy-2-(prop-2'-enyl)-9,10-anthraquinone

Guidance literature:: Multi-step reaction with 2 steps

1: 95 percent / TBAF / tetrahydrofuran; dimethylformamide / 48 h

2: 92 percent / glucose; aq. NaHCO₃ / butan-1-ol / 1.83 h / Heating

With D-glucose; tetrabutyl ammonium fluoride; sodium hydrogencarbonate; In tetrahydrofuran; N,N-dimethyl-formamide; butan-1-ol;
DOI:10.1021/ol048478l

Reference yield:

: 64302-83-6
1-(prop-2'-enyloxy)anthraquinone

: 64302-87-0
1-hydroxy-2-(prop-2'-enyl)-9,10-anthraquinone

: 64302-88-1
1-Hydroxy-2-((E)-propenyl)-anthraquinone

Guidance literature:: With D-glucose; In N,N-dimethyl-formamide; at 125 ℃; for 8h; Yield given. Yields of byproduct given;
DOI:10.1080/00397919408011730