7-METHOXY-1,2,3,4-TETRAHYDRO-ISOQUINOLINE

Base Information

• Chemical Name: 7-METHOXY-1,2,3,4-TETRAHYDRO-ISOQUINOLINE
• CAS No.: 43207-78-9
• Molecular Formula: C10H13NO
• Molecular Weight: 163.219
• Hs Code.: 2933499090
• Mol file: 43207-78-9.mol

Synonyms:Weberidine;7-Methoxy-1,2,3,4-Tetrahydro-Isoquinoline;

Chemical Property of 7-METHOXY-1,2,3,4-TETRAHYDRO-ISOQUINOLINE

Chemical Property:

• Melting Point: 190 °C
• Boiling Point: 283.615 °C at 760 mmHg
• PKA: 9.73±0.20(Predicted)
• Flash Point: 109.208 °C
• PSA: 21.26000
• Density: 1.044 g/cm³
• LogP: 1.66970
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature

Purity/Quality:

98%,99%, ^*data from raw suppliers

7-Methoxy-1,2,3,4-tetrahydroisoquinoline ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 7-METHOXY-1,2,3,4-TETRAHYDRO-ISOQUINOLINE

There total 29 articles about 7-METHOXY-1,2,3,4-TETRAHYDRO-ISOQUINOLINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

7-methoxy-3,4-dihydro-2H-isoquinolin-1-one (22246-04-4) → 7-methoxy-1,2,3,4-tetrahydroisoquinoline (43207-78-9)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; for 3h; Cooling with ice; Reflux;

Reference yield: 83.0%

2-formyl-1,2,3,4-tetrahydro-7-methoxyisoquinoline (212185-04-1) → 7-methoxy-1,2,3,4-tetrahydroisoquinoline (43207-78-9)

Guidance literature:

With sodium hydroxide; In ethanol; Ambient temperature;

DOI:10.1248/cpb.46.918

Reference yield: 81.0%

7-methoxyisoquinoline (39989-39-4) → 7-methoxy-1,2,3,4-tetrahydroisoquinoline (43207-78-9)

Guidance literature:

With ammonia; sodium; In ethanol; for 1.08333h;

DOI:10.1039/c3ob42254b

upstream raw materials:

7-methoxyisoquinoline

7-methoxy-3,4-dihydro-2H-isoquinolin-1-one

N-(3-methoxybenzyl)aminoacetaldehyde dimethyl acetal

N-(3,4-dichlorobenzylsulfonyl)-7-methoxy-1,2,3,4-tetrahydroisoquinoline

Downstream raw materials:

7-methoxy-1,2,3,4-tetrahydro-isoquinoline; picrate

7-hydroxy-1,2,3,4-tetrahydroisoquinoline hydrobromide

benzyl 7-(2-iodoethoxy)-1,2,3,4-tetrahydroisoquinolin-2-carboxylate

7-(4-ethoxycarbonylpiperidin-4-ylmethoxy)-1,2,3,4-tetrahydroisoquinoline-2-carboxylic acid benzyl ester

Refernces

• 1、 Jing, Dong,Lu, Cong,Chen, Zhuo,Jin, Songyang,Xie, Lijuan,Meng, Ziyi,Su, Zhishan,Zheng, Ke. "Light-Driven Intramolecular C?N Cross-Coupling via a Long-Lived Photoactive Photoisomer Complex". supporting information. p. 14666 - 14672. Retrieved 2019/09/06.
• 2、 -. "Tyrosine Kinase Inhibitor And Uses Thereof". Paragraph 0437-0438. . Retrieved 2017/05/15.