7-METHOXY-ISOQUINOLINE

Base Information

• Chemical Name: 7-METHOXY-ISOQUINOLINE
• CAS No.: 39989-39-4
• Molecular Formula: C10H9NO
• Molecular Weight: 159.188
• Hs Code.: 2933499090
• Mol file: 39989-39-4.mol

Synonyms:7-Methoxy-isoquinoline;

Chemical Property of 7-METHOXY-ISOQUINOLINE

Chemical Property:

• Vapor Pressure: 0.003mmHg at 25°C
• Refractive Index: 1.611
• Boiling Point: 295.593 °C at 760 mmHg
• PKA: 5.54±0.10(Predicted)
• Flash Point: 108.428 °C
• PSA: 22.12000
• Density: 1.131 g/cm³
• LogP: 2.24340
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

99% ^*data from raw suppliers

7-Methoxyisoquinoline ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi,Xn
• Statements: 22

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 7-METHOXY-ISOQUINOLINE

There total 22 articles about 7-METHOXY-ISOQUINOLINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

(3-methoxy)-benzyliminoacetal (90908-99-9) → 7-methoxyisoquinoline (39989-39-4)

Guidance literature:

With boron trifluoride diethyl etherate; trifluoroacetic anhydride; at 0 - 20 ℃;

DOI:10.1016/j.bmcl.2005.10.102

Reference yield: 42.0%

(E)-3-{2-[(E)-tert-Butylimino-methyl]-4-methoxy-phenyl}-acrylonitrile → 7-methoxyisoquinoline (39989-39-4) + hydrogen cyanide (74-90-8) + isobutene (115-11-7,15220-85-6)

Guidance literature:

In diphenylether; 1,3,5-trimethyl-benzene; at 200 ℃; for 8h;

DOI:10.1016/S0040-4039(00)88725-0

Reference yield: 40.0%

2,4,6-Trimethyl-benzenesulfonate2-amino-7-methoxy-isoquinolinium; (84900-37-8) → 7-methoxyisoquinoline (39989-39-4) + 8-Methoxy-3H-benzo[d][1,2]diazepine

Guidance literature:

With potassium hydroxide; In methanol; Irradiation;

DOI:10.1248/cpb.30.3764

upstream raw materials:

N-(3-methoxybenzyl)-N-tosylaminoacetaldehyde dimethyl acetal

2,2-diethoxy-N-(3-methoxybenzyl)ethanamine

2,4,6-Trimethyl-benzenesulfonate2-amino-7-methoxy-isoquinolinium;

(2,2-Dimethoxy-ethyl)-[1-(3-methoxy-phenyl)-meth-(Z)-ylidene]-amine

Downstream raw materials:

7-methoxy-N-methyl-1,2,3,4-tetrahydroisoquinoline

isoquinolin-7-ol

1-iodo-7-methoxyisoquinoline

7-methoxy-2H-isoquinolin-1-one

Refernces

• 1、 Middleton, Donald S.,Maw, Graham N.,Challenger, Clare,Jessiman, Alan,Johnson, Patrick S.,Million, William A.,Nichols, Carly L.,Price, Jenny A.,Trevethick, Michael. "Highly potent and selective zwitterionic agonists of the δ-opioid receptor. Part 1". . p. 905 - 910. Retrieved 2008/12/20.
• 2、 -. "AMINOISOQUINOLINE DERIVATIVES". . . Retrieved 2008/06/13.