DL-BETA-PROLINOL HCL

Base Information

• Chemical Name: DL-BETA-PROLINOL HCL
• CAS No.: 644971-22-2
• Molecular Formula: C5H11NO.ClH
• Molecular Weight: 137.60800
• Hs Code.: 2933990090
• Mol file: 644971-22-2.mol

Synonyms:pyrrolidin-3-ylmethanol,hydrochloride;

Chemical Property of DL-BETA-PROLINOL HCL

Chemical Property:

• Vapor Pressure: 0.0273mmHg at 25°C
• Boiling Point: 218.1oC at 760 mmHg
• Flash Point: 85.7oC
• PSA: 32.26000
• LogP: 0.71900
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

97% ^*data from raw suppliers

3-PyrrolidinemethanolHydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 3-Pyrrolidinemethanol Hydrochloride is used in the preparation of imidazo[1,2-a]pyridine derivatives for treatment of diseases involving fibrotic diseases, proliferative diseases, inflammatory diseases, autoimmune diseases, respiratory diseases, cardiovascular diseases, neurodegenerative diseases, and dermatologic disorder

Technology Process of DL-BETA-PROLINOL HCL

There total 1 articles about DL-BETA-PROLINOL HCL which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

tert-butyl 3-(hydroxymethyl)pyrrolidine-1-carboxylate (114214-69-6) → pyrrolidine-3-yl methanol hydrochloride (644971-22-2,1316087-88-3,1227157-98-3)

Guidance literature:

With hydrogenchloride; In methanol; at 0 - 20 ℃; for 2h; Inert atmosphere;

Reference yield:

pyrrolidine-3-yl methanol hydrochloride (644971-22-2,1316087-88-3,1227157-98-3) + 5-bromo-2-fluorobenzaldehyde (93777-26-5) → 5-bromo-2-[3-(hydroxymethyl)pyrrolidin-1-yl]benzaldehyde (742100-49-8)

Guidance literature:

With sodium carbonate; In water; dimethyl sulfoxide; at 75 ℃; for 5h;

Reference yield:

pyrrolidine-3-yl methanol hydrochloride (644971-22-2,1316087-88-3,1227157-98-3) + 2,4-bis(trifluoromethyl)benzyl bromide (140690-56-8) → {1-[2,4-bis(trifluoromethyl)benzyl]pyrrolidin-3-yl}methanol (1422129-37-0)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 3h;

upstream raw materials:

tert-butyl 3-(hydroxymethyl)pyrrolidine-1-carboxylate

Downstream raw materials:

5-bromo-2-[3-(hydroxymethyl)pyrrolidin-1-yl]benzaldehyde

(1-(2,6-dimethylphenyl)pyrrolidin-3-yl)methanol

{1-[2,4-bis(trifluoromethyl)benzyl]pyrrolidin-3-yl}methanol

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