93777-26-5

Basic information

• Product Name: 5-Bromo-2-fluorobenzaldehyde
• Synonyms: LABOTEST-BB LT01143303;2-FLUORO-5-BROMOBENZALDEHYDE;5-BROMO-2-FLUOROBENZALDEHYDE;AKOS BBS-00003261;5-Bromo-2-Fluorobenzaldehyde 2-Fluoro-5-Bromobenzaldehyde;5-Bromo-2-fluorobenzaldehyde 98%;5-Bromo-2-fluorobenzaldehyde98%;Benzaldehyde, 5-bromo-2-fluoro-
• CAS NO: 93777-26-5
• Molecular Formula: C₇H₄BrFO
• Molecular Weight: 203.01
• EINECS: 298-056-6
• Product Categories: Fluorin-contained benzaldehyde series;Carbonyl Compounds;Halides;Aromatic Aldehydes & Derivatives (substituted);Benzaldehyde;API intermediates;Adehydes, Acetals & Ketones;Bromine Compounds;Fluorine Compounds;Aldehydes;C7;Carbonyl Compounds;Benzaldehyde series
• Mol File: 93777-26-5.mol
• Article Data: 9

Chemical Properties

• Melting Point: 58-62°C
• Boiling Point: 230 °C(lit.)
• Flash Point: 229 °F
• Appearance: clear yellowish liquid after melting
• Density: 1.71 g/mL at 25 °C(lit.)
• Vapor Pressure: 0.0603mmHg at 25°C
• Refractive Index: n20/D 1.57(lit.)
• Storage Temp.: 2-8°C
• Water Solubility: INSOLUBLE
• Sensitive: Air Sensitive
• BRN: 7632798
• CAS DataBase Reference: 5-Bromo-2-fluorobenzaldehyde(CAS DataBase Reference)
• NIST Chemistry Reference: 5-Bromo-2-fluorobenzaldehyde(93777-26-5)
• EPA Substance Registry System: 5-Bromo-2-fluorobenzaldehyde(93777-26-5)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36-37/39
• WGK Germany: 3
• HazardClass: IRRITANT
• Hazardous Substances Data: 93777-26-5(Hazardous Substances Data)

Usage

Uses

5-Bromo-2-fluorobenzaldehyde is used for the preparation of benzimidazole derivatives as inhibitors of leukotriene production.

InChI:InChI=1/C9H8ClFO/c1-6(12)5-7-8(10)3-2-4-9(7)11/h2-4H,5H2,1H3

Upstream product

• 99725-12-9 4-bromo-2-(bromomethyl)-1-fluorobenzene 
• 3132-99-8 m-bromobenzoic aldehyde 
• 221030-92-8 4-Bromo-1-fluoro-2-vinyl-benzene 
• 446-52-6 2-Fluorobenzaldehyde 
• 107-31-3 Methyl formate 
• 460-00-4 1-Bromo-4-fluorobenzene 
• 68-12-2 N,N-dimethyl-formamide 

Downstream Products

• 602326-08-9 5-bromo-2-(2,4-dibromophenoxy)benzaldehyde 
• 329347-34-4 4-(4-bromo-2-formyl-N-allylanilino)butyric acid 
• 329347-25-3 4-(4-bromo-2-formyl-N-butylanilino)-butyric acid 
• 356039-77-5 5-(4-bromo-2-formyl-N-methylanilino)pentanoic acid 
• 329347-35-5 4-[4-bromo-2-formyl-N-(2-methoxybenzyl)anilino]butyric acid 
• 850789-61-6 5-bromo-2-[(2-dimethylaminoethyl)methylamino]benzaldehyde 
• 1016544-64-1 (5-bromo-2-fluorophenyl)(3,4,5-trimethoxyphenyl)methanol 
• 34159-05-2 N-(4-bromo-2-formylphenyl)-4-methylbenzenesulfonamide 
• 289718-03-2 5-bromo-2-(3,4-dichloro-phenoxy)-benzaldehyde 
• 951136-78-0 C₁₄H₇BrClF₃O₂ 
• 882670-77-1 (6-bromo-quinazolin-2-yl)-methylamine 
• 882670-93-1 6-bromo-2-iodoquinazoline 
• 882671-99-0 (6-bromo-quinazolin-2-yl)-phenyl-amine 

Relevant articles and documents

Copper-Catalyzed Oxidative Difunctionalization of Terminal Unactivated Alkenes

The copper(II)-promoted free-radical oxidative difunctionalization of terminal alkenes to access ketoazides by utilizing molecular oxygen has been reported. A series of styrene derivatives have been evaluated and were found to be compatible to give the desired difunctionalized products in moderate to good yields. The role of molecular oxygen both as an oxidant and oxygen atom source in this catalytic transformation has been unquestionably demonstrated by 18O-labeling studies and a radical mechanistic pathway involving the oxidative formation of azidyl radicals is also designed. This environment-friendly catalytic oxidative protocol can transform aldehyde to nitrile.

Preparation method of 2-fluoro-5-bromobenzaldehyde

The invention relates to a preparation method of 2-fluoro-5-bromobenzaldehyde as a medicine intermediate. O-fluorobenzaldehyde and a bromination reagent undergo a reaction in the presence of Lewis acid as a catalyst and the reaction product is subjected to reduced pressure distillation so that 2-fluoro-5-bromobenzaldehyde with a high yield and high content is obtained. The preparation method has the characteristics of easy availability of raw materials, less reaction processes, high yield and low cost.

ANILINE DERIVATIVES,THEIR PREPARATION AND THEIR THERAPEUTIC APPLICATION

The present invention relates to aniline derivatives, to their preparation and to their therapeutic application.