Butanoic acid, 4-[[(1,1-dimethylethyl)diphenylsilyl]oxy]-3-[(4-methoxyphenyl)methoxy]-2- [(tetrahydro-2H-pyran-2-yl)oxy]-, 1,1-dimethylethyl ester, (2S,3R)-

Base Information

Chemical Name:Butanoic acid, 4-[[(1,1-dimethylethyl)diphenylsilyl]oxy]-3-[(4-methoxyphenyl)methoxy]-2- [(tetrahydro-2H-pyran-2-yl)oxy]-, 1,1-dimethylethyl ester, (2S,3R)-
CAS No.:644981-39-5
Molecular Formula:C37H50O7Si
Molecular Weight:634.885
Hs Code.:

Butanoic acid,
4-[[(1,1-dimethylethyl)diphenylsilyl]oxy]-3-[(4-methoxyphenyl)methoxy]-2-
[(tetrahydro-2H-pyran-2-yl)oxy]-, 1,1-dimethylethyl ester, (2S,3R)-

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Chemical Property of Butanoic acid, 4-[[(1,1-dimethylethyl)diphenylsilyl]oxy]-3-[(4-methoxyphenyl)methoxy]-2- [(tetrahydro-2H-pyran-2-yl)oxy]-, 1,1-dimethylethyl ester, (2S,3R)-

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Technology Process of Butanoic acid, 4-[[(1,1-dimethylethyl)diphenylsilyl]oxy]-3-[(4-methoxyphenyl)methoxy]-2- [(tetrahydro-2H-pyran-2-yl)oxy]-, 1,1-dimethylethyl ester, (2S,3R)-

There total 6 articles about Butanoic acid, 4-[[(1,1-dimethylethyl)diphenylsilyl]oxy]-3-[(4-methoxyphenyl)methoxy]-2- [(tetrahydro-2H-pyran-2-yl)oxy]-, 1,1-dimethylethyl ester, (2S,3R)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 110-87-2
3,4-dihydro-2H-pyran

: 644981-38-4
tert-butyl (2S,3R)-4-(tert-butyldiphenylsilyl)oxy-2-hydroxy-3-(4-methoxybenzyl)oxybutanoate

: 644981-39-5
tert-butyl (2S,3R)-4-(tert-butyldiphenylsilyl)oxy-3-(4-methoxybenzyl)oxy-2-(tetrahydropyran-2-yl)oxybutanoate

Guidance literature:: With pyridinium p-toluenesulfonate; In dichloromethane; for 5h;
DOI:10.1002/anie.200352629 DOI:10.1002/chem.200601212

Reference yield:

: 117384-46-0
di-tert-butyl D-tartrate

: 644981-39-5
tert-butyl (2S,3R)-4-(tert-butyldiphenylsilyl)oxy-3-(4-methoxybenzyl)oxy-2-(tetrahydropyran-2-yl)oxybutanoate

Guidance literature:: Multi-step reaction with 4 steps

1.1: Bu₂SnO / toluene / 2 h / Heating

1.2: 92 percent / cesium fluoride / dimethylformamide / 10 h

2.1: LiBH₄ / tetrahydrofuran / 4 h / 20 °C

2.2: 24.5 g / LiBH₄ / tetrahydrofuran / 4 h / -78 °C

3.1: 97 percent / imidazole / CH₂Cl₂ / 0.5 h / 0 °C

4.1: 95 percent / pyridinium p-toluenesulfonate / CH₂Cl₂ / 5 h

With 1H-imidazole; lithium borohydride; pyridinium p-toluenesulfonate; di(n-butyl)tin oxide; In tetrahydrofuran; dichloromethane; toluene;
DOI:10.1002/chem.200601212

Reference yield:

: 644981-36-2
di-tert-butyl (2S,3S)-2-hydroxy-3-(4-methoxybenzyl)oxybutanedioate

: 644981-39-5
tert-butyl (2S,3R)-4-(tert-butyldiphenylsilyl)oxy-3-(4-methoxybenzyl)oxy-2-(tetrahydropyran-2-yl)oxybutanoate

Guidance literature:: Multi-step reaction with 3 steps

1.1: LiBH₄ / tetrahydrofuran / 4 h / 20 °C

1.2: 24.5 g / LiBH₄ / tetrahydrofuran / 4 h / -78 °C

2.1: 97 percent / imidazole / CH₂Cl₂ / 0.5 h / 0 °C

3.1: 95 percent / pyridinium p-toluenesulfonate / CH₂Cl₂ / 5 h

With 1H-imidazole; lithium borohydride; pyridinium p-toluenesulfonate; In tetrahydrofuran; dichloromethane;
DOI:10.1002/chem.200601212