L-Leucine, N-[N-[(1,1-dimethylethoxy)carbonyl]-D-phenylalanyl]-, ethyl ester

Base Information

Chemical Name:L-Leucine, N-[N-[(1,1-dimethylethoxy)carbonyl]-D-phenylalanyl]-, ethyl ester
CAS No.:64566-43-4
Molecular Formula:C₂₂H₃₄N₂O₅
Molecular Weight:406.522
Hs Code.:

Synonyms:

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Chemical Property of L-Leucine, N-[N-[(1,1-dimethylethoxy)carbonyl]-D-phenylalanyl]-, ethyl ester

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Technology Process of L-Leucine, N-[N-[(1,1-dimethylethoxy)carbonyl]-D-phenylalanyl]-, ethyl ester

There total 3 articles about L-Leucine, N-[N-[(1,1-dimethylethoxy)carbonyl]-D-phenylalanyl]-, ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 64-17-5
ethanol

: 64152-76-7
methyl (S)-2-((S)-2-(tert-butoxycarbonylamino)-3-phenylpropanamido)-4-methylpentanoate

: 64566-43-4,85208-90-8
Boc-Phe-Leu-OEt

Guidance literature:: With 1,8-diazabicyclo[5.4.0]undec-7-ene; lithium bromide; for 0.1h; Ambient temperature;
DOI:10.1002/hlca.19910740520

Reference yield:

: 13734-34-4
N-tert-butoxycarbonyl-L-phenylalanine

: 64566-43-4,85208-90-8
Boc-Phe-Leu-OEt

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) ClCO₂Et, N-methylmorpholine, 2.) N-methylmorpholine / 1.) THF, -15 deg C, 8 min, 2.) H₂O, THF, -15 deg to r.t., 24 h

2: 97 percent / LiBr, 1,8-diazabicyclo<5.4.0>undec-7-ene (DBU) / 0.1 h / Ambient temperature

With 4-methyl-morpholine; chloroformic acid ethyl ester; 1,8-diazabicyclo[5.4.0]undec-7-ene; lithium bromide;
DOI:10.1002/hlca.19910740520

Reference yield:

: 7517-19-3
methyl (L)-leucinate hydrochloride

: 64566-43-4,85208-90-8
Boc-Phe-Leu-OEt

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) ClCO₂Et, N-methylmorpholine, 2.) N-methylmorpholine / 1.) THF, -15 deg C, 8 min, 2.) H₂O, THF, -15 deg to r.t., 24 h

2: 97 percent / LiBr, 1,8-diazabicyclo<5.4.0>undec-7-ene (DBU) / 0.1 h / Ambient temperature

With 4-methyl-morpholine; chloroformic acid ethyl ester; 1,8-diazabicyclo[5.4.0]undec-7-ene; lithium bromide;
DOI:10.1002/hlca.19910740520