4-ethoxycarbonyl-2-quinolone

Base Information

• Chemical Name: 4-ethoxycarbonyl-2-quinolone
• CAS No.: 5466-27-3
• Molecular Formula: C12H11 N O3
• Molecular Weight: 217.224
• Hs Code.: 2933790090
• Mol file: 5466-27-3.mol

Synonyms:Cinchoninicacid, 2-hydroxy-, ethyl ester (7CI,8CI); 2-Hydroxy-4-carbethoxyquinoline;4-(Ethoxycarbonyl)-2-quinolone; Ethyl 1,2-dihydro-2-oxoquinoline-4-carboxylate;Ethyl 2-hydroxycinchoninate; NSC 25661

Chemical Property of 4-ethoxycarbonyl-2-quinolone

Chemical Property:

• Vapor Pressure: 2.7E-07mmHg at 25°C
• Boiling Point: 421°C at 760 mmHg
• Flash Point: 208.4°C
• PSA: 59.16000
• Density: 1.246g/cm³
• LogP: 1.70480

Purity/Quality:

99%min ^*data from raw suppliers

Ethyl2-Hydroxyquinoline-4-carboxylate 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-ethoxycarbonyl-2-quinolone

There total 9 articles about 4-ethoxycarbonyl-2-quinolone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

2-hydroxyquinoline-4-carboxylic acid (15733-89-8,84906-81-0) + ethanol (64-17-5) → ethyl 2-hydroxyquinoline-4-carboxylate (5466-27-3)

Guidance literature:

With sulfuric acid; for 0.166667h; microwave irradiation;

DOI:10.1080/00397910500184719

Reference yield:

malonic acid (141-82-2) + indole-2,3-dione (91-56-5,1186480-61-4,84788-92-1) → ethyl 2-hydroxyquinoline-4-carboxylate (5466-27-3)

Guidance literature:

With hydrogenchloride; ethanol; ammonia;

DOI:10.1021/ja01307a043

Reference yield:

indole-2,3-dione (91-56-5,1186480-61-4,84788-92-1) → ethyl 2-hydroxyquinoline-4-carboxylate (5466-27-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 68 percent / acetic acid / 0.25 h

2: 99 percent / sulfuric acid / 0.17 h / microwave irradiation

With sulfuric acid; acetic acid;

DOI:10.1080/00397910500184719

upstream raw materials:

2-hydroxyquinoline-4-carboxylic acid

2-ethoxy-quinoline-4-carboxylic acid ethyl ester

malonic acid

indole-2,3-dione

Downstream raw materials:

2-hydroxy-quinoline-4-carboxylic acid hydrazide

ethyl 2-(tosyloxy)quinoline-4-carboxylate

ethyl 2-(perfluorophenyl)quinoline-4-carboxylate

4-hydroxymethyl-3,4-dihydro-1H-quinolin-2-one

Refernces