(1S,2R,3S,4R)-3,4-Dihydroxy-1,2-epoxy-1,2,3,4-tetrahydrodibenz(c,h)acridine

Base Information

Chemical Name:(1S,2R,3S,4R)-3,4-Dihydroxy-1,2-epoxy-1,2,3,4-tetrahydrodibenz(c,h)acridine
CAS No.:93780-98-4
Molecular Formula:C₂₁H₁₅NO₃
Molecular Weight:329.355
Hs Code.:
UNII:ZTD2T2KGSU
Nikkaji Number:J1.454.926I

Synonyms:ZTD2T2KGSU;(1S,2R,3S,4R)-3,4-Dihydroxy-1,2-epoxy-1,2,3,4-tetrahydrodibenz(c,h)acridine;93780-98-4;CCRIS 2355;(1S,2R,3S,4R)-3,4-Dihydroxy-1,2-epoxy-1,2,3,4-tetrahydrobenz(c,h)acridine;UNII-ZTD2T2KGSU;[1S,2R,3S,4R]-3,4-DIHYDROXY-1,2-EPOXY-1,2,3,4-TETRAHYDROBENZ[C,H]ACRIDINE;Benz(c)oxireno(5,6)benz(1,2-h)acridine-2,3-diol, 1a,2,3,13c-tetrahydro-, (1aR-(1a-alpha,2-alpha,3-beta,13c-alpha))-;J1.454.926I;Q27295877;(1AR,2S,3R,13CS)-1A,2,3,13C-TETRAHYDROBENZO(C)(1)BENZOXIRENO(2,3-H)ACRIDINE-2,3-DIOL;BENZ(C)OXIRENO(5,6)BENZ(1,2-H)ACRIDINE-2,3-DIOL, 1A,2,3,13C-TETRAHYDRO-, (1AR,2S,3R,13CS)-;BENZ(C)OXIRENO(5,6)BENZ(1,2-H)ACRIDINE-2,3-DIOL, 1A,2,3,13C-TETRAHYDRO-, (1AR-(1A.ALPHA.,2.ALPHA.,3.BETA.,13C.ALPHA.))-;BENZO(C)-1-BENZOXIRENO(2,3-H)ACRIDINE-2,3-DIOL, 1A,2,3,13C-TETRAHYDRO-, (1AR,2S,3R,13CS)-

Suppliers and Price of (1S,2R,3S,4R)-3,4-Dihydroxy-1,2-epoxy-1,2,3,4-tetrahydrodibenz(c,h)acridine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
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price

Total 1 raw suppliers

Chemical Property of (1S,2R,3S,4R)-3,4-Dihydroxy-1,2-epoxy-1,2,3,4-tetrahydrodibenz(c,h)acridine

Chemical Property:

Vapor Pressure:3.42E-18mmHg at 25°C
Boiling Point:657.7°Cat760mmHg
Flash Point:351.5°C
Density:1.527g/cm³
XLogP3:2.6
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:0
Exact Mass:329.10519334
Heavy Atom Count:25
Complexity:541

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:C1=CC=C2C(=C1)C=CC3=CC4=C(C5=C(C=C4)C(C(C6C5O6)O)O)N=C32
Isomeric SMILES:C1=CC=C2C(=C1)C=CC3=CC4=C(C5=C(C=C4)[C@H]([C@@H]([C@@H]6[C@H]5O6)O)O)N=C32

Technology Process of (1S,2R,3S,4R)-3,4-Dihydroxy-1,2-epoxy-1,2,3,4-tetrahydrodibenz(c,h)acridine

There total 11 articles about (1S,2R,3S,4R)-3,4-Dihydroxy-1,2-epoxy-1,2,3,4-tetrahydrodibenz(c,h)acridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 93716-13-3,93780-97-3,93780-99-5
1β,3α,4β-trihydroxy-2α-bromo-1,2,3,4-tetrahydrodibenzacridine

: 93780-98-4,93780-94-0
(1S,2R,3S,4R)-3,4-dihydroxy-1,2-epoxy-1,2,3,4-tetrahydrodibenzacridine

Guidance literature:: With Amberlite-400; In tetrahydrofuran; for 5h; Ambient temperature;
DOI:10.1021/jo00201a019

Reference yield:

: 90-15-3
α-naphthol

: 93780-98-4,93780-94-0
(1S,2R,3S,4R)-3,4-dihydroxy-1,2-epoxy-1,2,3,4-tetrahydrodibenzacridine

Guidance literature:: Multi-step reaction with 10 steps

1: 12.9 percent / 0.25 h / 250 °C

3: 88 percent / 25percent aq. NaOH / tetrahydrofuran; methanol / 5 h / Ambient temperature

4: 92 percent / pyridine / 24 h / Ambient temperature

5: 96 percent / NBS, AIBN / CCl₄ / 0.25 h / 60 - 62 °C

6: 66 percent / Li₂CO₃, LiF / hexamethylphosphoric acid triamide / 3 h / 85 - 90 °C

7: 93 percent / NH₃ / methanol; tetrahydrofuran / 4 h / Ambient temperature

9: 90 percent / aq. HCl, N-bromoacetamide (NBA) / tetrahydrofuran / 0.5 h / 0 - 5 °C

10: 70 percent / Amberlite-400 / tetrahydrofuran / 5 h / Ambient temperature

With pyridine; hydrogenchloride; sodium hydroxide; N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); Amberlite-400; ammonia; lithium carbonate; lithium fluoride; N-bromoacetamide; In tetrahydrofuran; methanol; tetrachloromethane; N,N,N,N,N,N-hexamethylphosphoric triamide;
DOI:10.1021/jo00201a019

Reference yield:

: 124508-39-0
trans-3,4-dihydroxy-1,2,3,4-tetrahydrodibenzacridine

: 93780-98-4,93780-94-0
(1S,2R,3S,4R)-3,4-dihydroxy-1,2-epoxy-1,2,3,4-tetrahydrodibenzacridine

Guidance literature:: Multi-step reaction with 7 steps

1: 92 percent / pyridine / 24 h / Ambient temperature

2: 96 percent / NBS, AIBN / CCl₄ / 0.25 h / 60 - 62 °C

3: 66 percent / Li₂CO₃, LiF / hexamethylphosphoric acid triamide / 3 h / 85 - 90 °C

4: 93 percent / NH₃ / methanol; tetrahydrofuran / 4 h / Ambient temperature

6: 90 percent / aq. HCl, N-bromoacetamide (NBA) / tetrahydrofuran / 0.5 h / 0 - 5 °C

7: 70 percent / Amberlite-400 / tetrahydrofuran / 5 h / Ambient temperature

With pyridine; hydrogenchloride; N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); Amberlite-400; ammonia; lithium carbonate; lithium fluoride; N-bromoacetamide; In tetrahydrofuran; methanol; tetrachloromethane; N,N,N,N,N,N-hexamethylphosphoric triamide;
DOI:10.1021/jo00201a019