2-Bromo-1,4-dimethoxynaphthalene

Base Information

• Chemical Name: 2-Bromo-1,4-dimethoxynaphthalene
• CAS No.: 64648-81-3
• Molecular Formula: C12H11BrO2
• Molecular Weight: 267.122
• DSSTox Substance ID: DTXSID40472484
• Nikkaji Number: J613.465C
• Wikidata: Q82301450
• Mol file: 64648-81-3.mol

Synonyms:2-bromo-1,4-dimethoxynaphthalene;64648-81-3;1,4-Dimethoxy-3-bromonaphthalene;2-bromo-1,4-dimethoxy-naphthalene;SCHEMBL3747262;DTXSID40472484;CUDFWADTRPHTIQ-UHFFFAOYSA-N;1,4-dimethoxy-2-bromo-naphthalene;1,4-dimethoxy-3-bromo-naphthalene;AB8352;MFCD14582916;AKOS027254787;(S)-1-METHYL-2-OXO-IMIDAZOLIDINE-4-CARBOXYLICACIDBENZYLESTER

Chemical Property of 2-Bromo-1,4-dimethoxynaphthalene

Chemical Property:

• XLogP3: 3.8
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 265.99424
• Heavy Atom Count: 15
• Complexity: 210

Purity/Quality:

98%min ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: COC1=CC(=C(C2=CC=CC=C21)OC)Br

Technology Process of 2-Bromo-1,4-dimethoxynaphthalene

There total 1 articles about 2-Bromo-1,4-dimethoxynaphthalene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1,4-dimethoxynaphthalene (10075-62-4) → iodobenzene (591-50-4) + 2-bromo-1,4-dimethoxynaphthalene (64648-81-3)

Guidance literature:

With trimethylsilyl bromide; [bis(acetoxy)iodo]benzene; for 0.0833333h; Mechanism; other substrate;

DOI:10.1021/jo970525i

Reference yield: 84.0%

2-bromo-1,4-dimethoxynaphthalene (64648-81-3) + benzyl 2-(benzyloxy)benzoate (14389-87-8) → [2-(benzyloxy)phenyl](1,4-dimethoxynaphthalen-2-yl)methanone (1258196-68-7)

Guidance literature:

2-bromo-1,4-dimethoxynaphthalene; With n-butyllithium; In tetrahydrofuran; at -78 ℃; for 0.833333h; Inert atmosphere;

benzyl 2-(benzyloxy)benzoate; In tetrahydrofuran; at -78 ℃; for 0.5h; Inert atmosphere;

DOI:10.1021/jo101873v

Reference yield: 83.0%

2-bromo-1,4-dimethoxynaphthalene (64648-81-3) + 4-(methoxymethoxy)phenylboronic acid (162662-27-3) → 1,4-Dimethoxy-2-(4-methoxymethoxy-phenyl)-naphthalene (132113-71-4)

Guidance literature:

With sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In toluene;

DOI:10.1016/S0040-4039(00)97484-7

upstream raw materials:

1,4-dimethoxynaphthalene

Downstream raw materials:

2-(1,4-dimethoxy-2-naphthoyl)-benzoic acid

1,4-Dimethoxy-2-(4-methoxymethoxy-phenyl)-naphthalene

5,12-dimethoxy-6,13-tetracenequinone

(S)-1,4-dimethoxy-2-p-tolylsulfinylnaphthalene