4-(N-Acetyl)piperidinyl 2-(5-Methoxy)phenol Ketone

Base Information

• Chemical Name: 4-(N-Acetyl)piperidinyl 2-(5-Methoxy)phenol Ketone
• CAS No.: 64671-18-7
• Molecular Formula: C15H19NO4
• Molecular Weight: 277.32
• Mol file: 64671-18-7.mol

Synonyms:(1-Acetylpiperidin-4-yl)(2-hydroxy-4-methoxyphenyl)methanone;1-[4-(2-Hydroxy-4-methoxy-benzoyl)-piperidin-1-yl]-ethanone;

Chemical Property of 4-(N-Acetyl)piperidinyl 2-(5-Methoxy)phenol Ketone

Chemical Property:

• Melting Point: 139-141 °C(Solv: ethyl acetate (141-78-6))
• Boiling Point: 492.5 °C at 760 mmHg
• PKA: 7.50±0.35(Predicted)
• Flash Point: 251.7 °C
• PSA: 66.84000
• Density: 1.215 g/cm³
• LogP: 1.77990
• Solubility.: Dichloromethane, Methanol

Purity/Quality:

99% ^*data from raw suppliers

4-(N-Acetyl)piperidinyl2-(5-Methoxy)phenolKetone ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Intermediate in the preparation of Risperidone derivatives.

Technology Process of 4-(N-Acetyl)piperidinyl 2-(5-Methoxy)phenol Ketone

There total 3 articles about 4-(N-Acetyl)piperidinyl 2-(5-Methoxy)phenol Ketone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-acetyl-piperidine-4-carboxylic acid (25503-90-6) → 1-acetyl-4-(2-hydroxy-4-methoxybenzoyl)piperidine (64671-18-7)

Guidance literature:

Multi-step reaction with 2 steps

1: SOCl₂ / 1,2-dichloro-ethane / 40 - 65 °C

2: AlCl₃ / 2 h / Heating

With aluminium trichloride; thionyl chloride; In 1,2-dichloro-ethane;

DOI:10.1021/jm00383a012

Reference yield:

1-acetylpiperidine-4-carbonyl chloride (59084-16-1) + 1,3-Dimethoxybenzene (151-10-0) → 1-acetyl-4-(2-hydroxy-4-methoxybenzoyl)piperidine (64671-18-7)

Guidance literature:

With aluminium trichloride; for 2h; Heating;

DOI:10.1021/jm00383a012

Reference yield:

→ 1-acetyl-4-(2-hydroxy-4-methoxybenzoyl)piperidine (64671-18-7)

Guidance literature:

m-Dimethoxybenzol, entspr. Saeurechlorid;

upstream raw materials:

1-acetylpiperidine-4-carbonyl chloride

1,3-Dimethoxybenzene

1-acetyl-piperidine-4-carboxylic acid

Downstream raw materials:

4-(2-hydroxy-4-methoxybenzoyl)piperidine hydrochloride

phenylmethyl 4-(2-hydroxy-4-methoxybenzoyl)-1-piperidinecarboxylate

1-acetyl-4-(2-hydroxy-4-methoxy-benzoyl)piperidine o-acetyl oxime

4-(2-hydroxy-4-methoxybenzoyl)piperidine

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