(2-Hydroxy-4-methoxyphenyl)(4-piperidinyl)methanone hydrochloride

Base Information

Chemical Name:(2-Hydroxy-4-methoxyphenyl)(4-piperidinyl)methanone hydrochloride
CAS No.:84162-88-9
Molecular Formula:C13H17NO3.ClH
Molecular Weight:271.74000
Hs Code.:
DSSTox Substance ID:DTXSID40517440
Mol file:84162-88-9.mol

Synonyms:84162-88-9;2-(5-Methoxy)phenol 4-Piperidinyl Ketone Hydrochloride;(2-Hydroxy-4-methoxyphenyl)(4-piperidinyl)methanone hydrochloride;(2-hydroxy-4-methoxyphenyl)-piperidin-4-ylmethanone;hydrochloride;AFTKVIBPFXVQKY-UHFFFAOYSA-N;SCHEMBL10640839;DTXSID40517440;FT-0671317;4-(2-Hydroxy-4-methoxybenzoyl)piperidine hydrochloride;(2-Hydroxy-4-methoxyphenyl)(piperidin-4-yl)methanone--hydrogen chloride (1/1)

Suppliers and Price of (2-Hydroxy-4-methoxyphenyl)(4-piperidinyl)methanone hydrochloride

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

American Custom Chemicals Corporation
2-(5-METHOXY)PHENO- 4-PIPERIDINYL KETONE HYDROCHLORIDE 95.00%
5MG
$ 505.33

Total 3 raw suppliers

Chemical Property of (2-Hydroxy-4-methoxyphenyl)(4-piperidinyl)methanone hydrochloride

Chemical Property:

Melting Point:264-266 °C(Solv: ethanol (64-17-5))
PSA：58.56000
LogP:2.71390
Solubility.:Methanol
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:3
Exact Mass:271.0975211
Heavy Atom Count:18
Complexity:263

Purity/Quality:

97% ^*data from raw suppliers

2-(5-METHOXY)PHENO- 4-PIPERIDINYL KETONE HYDROCHLORIDE 95.00% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:COC1=CC(=C(C=C1)C(=O)C2CCNCC2)O.Cl
Uses Intermediate in the preparation of Risperidone derivatives.

Technology Process of (2-Hydroxy-4-methoxyphenyl)(4-piperidinyl)methanone hydrochloride

There total 4 articles about (2-Hydroxy-4-methoxyphenyl)(4-piperidinyl)methanone hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

: 64671-18-7
1-acetyl-4-(2-hydroxy-4-methoxybenzoyl)piperidine

: 84162-88-9
4-(2-hydroxy-4-methoxybenzoyl)piperidine hydrochloride

Guidance literature:: With hydrogenchloride; for 6h; Heating;
DOI:10.1021/jm00383a012

Reference yield:

: 25503-90-6
1-acetyl-piperidine-4-carboxylic acid

: 84162-88-9
4-(2-hydroxy-4-methoxybenzoyl)piperidine hydrochloride

Guidance literature:: Multi-step reaction with 3 steps

1: SOCl₂ / 1,2-dichloro-ethane / 40 - 65 °C

2: AlCl₃ / 2 h / Heating

3: 68 percent / 6 N aq. HCl / 6 h / Heating

With hydrogenchloride; aluminium trichloride; thionyl chloride; In 1,2-dichloro-ethane;
DOI:10.1021/jm00383a012

Reference yield:

: 59084-16-1
1-acetylpiperidine-4-carbonyl chloride

: 84162-88-9
4-(2-hydroxy-4-methoxybenzoyl)piperidine hydrochloride

Guidance literature:: Multi-step reaction with 2 steps

1: AlCl₃ / 2 h / Heating

2: 68 percent / 6 N aq. HCl / 6 h / Heating

With hydrogenchloride; aluminium trichloride;
DOI:10.1021/jm00383a012