Technology Process of Tetrahydro-2,8,4,6-(epoxyethanediylideneoxy)[1,3]dioxino[5,4-d]-1,3-dioxin
There total 8 articles about Tetrahydro-2,8,4,6-(epoxyethanediylideneoxy)[1,3]dioxino[5,4-d]-1,3-dioxin which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
toluene-4-sulfonic acid;
In
tetrahydrofuran;
for 5h;
Ambient temperature;
DOI:10.1021/jo00222a046
- Guidance literature:
-
Multi-step reaction with 7 steps
1: 48 percent / imidazole / dimethylformamide / 24 h / 0 - 20 °C
2: 1.) NaH / 1.) DMF, 30 min, 2.) DMF, 24 h
3: tetrabutylammonium fluoride / tetrahydrofuran / 30 h
4: (COCl)2, DMSO / CH2Cl2 / 1 h
5: NaBH4 / methanol; tetrahydrofuran / 0.33 h
6: 94 percent / H2 / 20percent Pd(OH)2/C / tetrahydrofuran / 3 h / 2585.7 Torr
7: 100 percent / p-TsOH*H2O / tetrahydrofuran / 5 h / Ambient temperature
With
1H-imidazole; sodium tetrahydroborate; oxalyl dichloride; tetrabutyl ammonium fluoride; hydrogen; sodium hydride; toluene-4-sulfonic acid; dimethyl sulfoxide;
palladium dihydroxide;
In
tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jo00222a046
- Guidance literature:
-
Multi-step reaction with 4 steps
1: (COCl)2, DMSO / CH2Cl2 / 1 h
2: NaBH4 / methanol; tetrahydrofuran / 0.33 h
3: 94 percent / H2 / 20percent Pd(OH)2/C / tetrahydrofuran / 3 h / 2585.7 Torr
4: 100 percent / p-TsOH*H2O / tetrahydrofuran / 5 h / Ambient temperature
With
sodium tetrahydroborate; oxalyl dichloride; hydrogen; toluene-4-sulfonic acid; dimethyl sulfoxide;
palladium dihydroxide;
In
tetrahydrofuran; methanol; dichloromethane;
DOI:10.1021/jo00222a046
