meso-4,6-di-O-benzyl-D-myo-inositol-1,3,5-O-orthoformate

Base Information

• Chemical Name: meso-4,6-di-O-benzyl-D-myo-inositol-1,3,5-O-orthoformate
• CAS No.: 98510-25-9
• Molecular Formula: C₂₁H₂₂O₆
• Molecular Weight: 370.402
• Mol file: 98510-25-9.mol

Synonyms:meso-4,6-di-O-benzyl-D-myo-inositol-1,3,5-O-orthoformate

Chemical Property of meso-4,6-di-O-benzyl-D-myo-inositol-1,3,5-O-orthoformate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of meso-4,6-di-O-benzyl-D-myo-inositol-1,3,5-O-orthoformate

There total 20 articles about meso-4,6-di-O-benzyl-D-myo-inositol-1,3,5-O-orthoformate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

racemic 2,4-di-O-benzyl-6-O-tosyl-myo-inositol 1,3,5-orthoformate → racemic 2,4-di-O-benzyl-myo-inositol 1,3,5-orthoformate (98510-25-9,98575-46-3,120330-03-2)

Guidance literature:

With magnesium; In methanol; for 24h;

DOI:10.1016/S0008-6215(02)00298-7

Reference yield: 92.0%

Benzoic acid (1S,5S,6S,7R,8S,9R)-8,9-bis-benzyloxy-2,4,10-trioxa-tricyclo[3.3.1.13,7]dec-6-yl ester → meso-4,6-di-O-benzyl-D-myo-inositol-1,3,5-O-orthoformate (98510-25-9)

Guidance literature:

With tert-butylamine; In methanol; for 20h; Heating;

DOI:10.1016/S0008-6215(98)00061-5

Reference yield: 75.0%

benzyl bromide (100-39-0) + myo-Inositol orthoformate (98510-20-4) → meso-4,6-di-O-benzyl-D-myo-inositol-1,3,5-O-orthoformate (98510-25-9)

Guidance literature:

myo-Inositol orthoformate; With lithium hydride; In N,N-dimethyl-formamide; at 20 ℃; for 0.5h;

benzyl bromide; at 20 ℃; for 48h; regioselective reaction;

DOI:10.1039/c3cc43663b

upstream raw materials:

benzyl bromide

myo-inositol monoorthoformate

myo-Inositol orthoformate

4/6-O-benzyl-myo-inositol 1,3,5-monoorthoformate

Downstream raw materials:

{[(8S,9R)-8,9-Bis-benzyloxy-2,4,10-trioxa-tricyclo[3.3.1.1^3,7]dec-(6E)-ylidene]-fluoro-methyl}-phosphonic acid diethyl ester

[Fluoro-((1S,2R,3S,4R,5R,6S)-2,3,4,5,6-pentahydroxy-cyclohexyl)-methyl]-phosphonic acid

[Fluoro-((1R,2S,3R,4R,5S,6R)-2,3,4,5,6-pentahydroxy-cyclohexyl)-methyl]-phosphonic acid

(1S,5S,7R,8S,9R)-8,9-Bis-benzyloxy-2,4,10-trioxa-tricyclo[3.3.1.1^3,7]decan-6-one