4-Chloro-2-pyridin-4-ylquinazoline

Base Information

Chemical Name:4-Chloro-2-pyridin-4-ylquinazoline
CAS No.:6484-27-1
Molecular Formula:C13H8ClN3
Molecular Weight:241.68
Hs Code.:2933990090
European Community (EC) Number:823-639-4
DSSTox Substance ID:DTXSID00406088
Wikidata:Q82210964
Mol file:6484-27-1.mol

Synonyms:4-chloro-2-pyridin-4-ylquinazoline;6484-27-1;4-chloro-2-(pyridin-4-yl)quinazoline;Quinazoline, 4-chloro-2-(4-pyridinyl)-;4-chloro-2-pyridin-4yl-quinazoline;SCHEMBL3461416;DTXSID00406088;RWUSMOWAZASBJI-UHFFFAOYSA-N;4-Chloro-2-(4-pyridinyl)quinazoline;AKOS000266898;CS-0244137;EN300-27247;Z235341195;3-METHYL-5-MORPHOLIN-4-YLMETHYL-FURAN-2-CARBOXYLICACID

Suppliers and Price of 4-Chloro-2-pyridin-4-ylquinazoline

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

American Custom Chemicals Corporation
4-CHLORO-2-PYRIDIN-4-YLQUINAZOLINE 95.00%
5G
$ 1548.26

American Custom Chemicals Corporation
4-CHLORO-2-PYRIDIN-4-YLQUINAZOLINE 95.00%
2.5G
$ 1227.82

American Custom Chemicals Corporation
4-CHLORO-2-PYRIDIN-4-YLQUINAZOLINE 95.00%
1G
$ 852.55

AK Scientific
4-Chloro-2-pyridin-4-ylquinazoline
1g
$ 608.00

AK Scientific
4-Chloro-2-pyridin-4-ylquinazoline
100mg
$ 253.00

Total 7 raw suppliers

Chemical Property of 4-Chloro-2-pyridin-4-ylquinazoline

Chemical Property:

PSA：38.67000
LogP:3.34520
XLogP3:3.4
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:1
Exact Mass:241.0406750
Heavy Atom Count:17
Complexity:255

Purity/Quality:

99%, ^*data from raw suppliers

4-CHLORO-2-PYRIDIN-4-YLQUINAZOLINE 95.00% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1=CC=C2C(=C1)C(=NC(=N2)C3=CC=NC=C3)Cl

Technology Process of 4-Chloro-2-pyridin-4-ylquinazoline

There total 10 articles about 4-Chloro-2-pyridin-4-ylquinazoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 6484-23-7
2-(pyridin-4'-yl)quinazolin-4-(3H)-one

: 6484-27-1
4-chloro-2-(pyridin-4-yl)quinazoline

Guidance literature:: With trichlorophosphate; Reflux;
DOI:10.1021/acs.jmedchem.7b00441

Reference yield:

: 14254-57-0
4-(chlorocarbonyl)pyridine

: 6484-27-1
4-chloro-2-(pyridin-4-yl)quinazoline

Guidance literature:: Multi-step reaction with 3 steps

1: Et₃N / tetrahydrofuran; CH₂Cl₂ / 6 h / 23 °C

2: NaOMe / toluene / 18 h / Heating

3: 1.) N,N-dimethylaniline, 2.) POCl₃ / 1.) C₆H₆, reflux, 30 min, 2.) C₆H₆, reflux, 6 h

With sodium methylate; N,N-dimethyl-aniline; triethylamine; trichlorophosphate; In tetrahydrofuran; dichloromethane; toluene;
DOI:10.1021/jm00018a014

Reference yield:

: 28144-70-9,88-68-6
anthranilic acid amide

: 6484-27-1
4-chloro-2-(pyridin-4-yl)quinazoline

Guidance literature:: Multi-step reaction with 3 steps

1: Et₃N / tetrahydrofuran; CH₂Cl₂ / 6 h / 23 °C

2: NaOMe / toluene / 18 h / Heating

3: 1.) N,N-dimethylaniline, 2.) POCl₃ / 1.) C₆H₆, reflux, 30 min, 2.) C₆H₆, reflux, 6 h

With sodium methylate; N,N-dimethyl-aniline; triethylamine; trichlorophosphate; In tetrahydrofuran; dichloromethane; toluene;
DOI:10.1021/jm00018a014