(3-TERT-BUTOXY)BENZALDEHYDE

Base Information

• Chemical Name: (3-TERT-BUTOXY)BENZALDEHYDE
• CAS No.: 64859-36-5
• Molecular Formula: C11H14O2
• Molecular Weight: 178.22800
• Hs Code.: 2912499000
• Mol file: 64859-36-5.mol

Synonyms:m-tert-Butoxy-benzaldehyd;3-t-butoxybenzaldehyde;3-TERT-BUTOXYBENZALDEHYDE;

Chemical Property of (3-TERT-BUTOXY)BENZALDEHYDE

Chemical Property:

• Boiling Point: 267.2±13.0 °C(Predicted)
• PSA: 26.30000
• Density: 1.020±0.06 g/cm3(Predicted)
• LogP: 2.67640

Purity/Quality:

97% ^*data from raw suppliers

3-[(2-Methylpropan-2-yl)oxy]benzaldehyde ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (3-TERT-BUTOXY)BENZALDEHYDE

There total 5 articles about (3-TERT-BUTOXY)BENZALDEHYDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 32.0%

tert-Butyl 2,2,2-trichloroacetimidate (98946-18-0) + meta-hydroxybenzaldehyde (100-83-4) → 3-t-butoxybenzaldehyde (64859-36-5)

Guidance literature:

With boron trifluoride diethyl etherate; In dichloromethane; cyclohexane; for 1h;

DOI:10.1021/jm020038h

Reference yield:

di-tert-butyl dicarbonate (24424-99-5) + meta-hydroxybenzaldehyde (100-83-4) → 3-t-butoxybenzaldehyde (64859-36-5)

Guidance literature:

meta-hydroxybenzaldehyde; With magnesium(II) perchlorate; In dichloromethane; at 20 ℃; for 0.166667h;

di-tert-butyl dicarbonate; In dichloromethane; for 14h; Reflux;

Reference yield:

(3-tert-butoxyphenyl)methanol (64859-35-4) → 3-t-butoxybenzaldehyde (64859-36-5)

Guidance literature:

In dichloromethane;

upstream raw materials:

(3-tert-butoxyphenyl)methanol

tert-Butyl 2,2,2-trichloroacetimidate

meta-hydroxybenzaldehyde

tert-butyl 3-methylphenyl ether

Downstream raw materials:

(3-tert-butoxy-benzyl)-(3-phenoxy-phenyl)-amine

Refernces

• 1、 Durley, Richard C.,Grapperhaus, Margaret L.,Hickory, Brian S.,Massa, Mark A.,Wang, Jane L.,Spangler, Dale P.,Mischke, Deborah A.,Parnas, Barry L.,Fobian, Yvette M.,Rath, Nigam P.,Honda, Dorothy D.,Zeng, Ming,Connolly, Daniel T.,Heuvelman, Deborah M.,Witherbee, Bryan J.,Melton, Michele A.,Glenn, Kevin C.,Krul, Elaine S.,Smith, Mark E.,Sikorski, James A.. "Chiral N,N-disubstituted trifluoro-3-amino-2-propanols are potent inhibitors of cholesteryl ester transfer protein". . p. 3891 - 3904. Retrieved 2007/10/03.