Technology Process of 1H-Pyrrole-1-carboxylic acid,
2,5-dihydro-2-[2-[[(phenylmethoxy)carbonyl]amino]ethyl]-,
1,1-dimethylethyl ester, (2R)-
There total 6 articles about 1H-Pyrrole-1-carboxylic acid,
2,5-dihydro-2-[2-[[(phenylmethoxy)carbonyl]amino]ethyl]-,
1,1-dimethylethyl ester, (2R)- which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 3.42 g / triethylamine / CH2Cl2 / 1 h / 0 °C
2: sodium azide / dimethylformamide / 1.5 h / 60 °C
3: triphenylphosphine / tetrahydrofuran / 7.5 h / 45 °C
4: sodium carbonate / dioxane; H2O / 1 h
With
sodium azide; sodium carbonate; triethylamine; triphenylphosphine;
In
tetrahydrofuran; 1,4-dioxane; dichloromethane; water; N,N-dimethyl-formamide;
4: Schotten-Baumann reaction;
DOI:10.1016/j.bmc.2004.10.060
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 72 percent / silver trifluoroacetate; N-methylmorpholine / tetrahydrofuran / 6 h / 0 - 20 °C
2: 67 percent / lithium borohydride / methanol; tetrahydrofuran / 1.25 h
3: 3.42 g / triethylamine / CH2Cl2 / 1 h / 0 °C
4: sodium azide / dimethylformamide / 1.5 h / 60 °C
5: triphenylphosphine / tetrahydrofuran / 7.5 h / 45 °C
6: sodium carbonate / dioxane; H2O / 1 h
With
4-methyl-morpholine; lithium borohydride; sodium azide; silver trifluoroacetate; sodium carbonate; triethylamine; triphenylphosphine;
In
tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; water; N,N-dimethyl-formamide;
1: Wolff rearrangement / 6: Schotten-Baumann reaction;
DOI:10.1016/j.bmc.2004.10.060
- Guidance literature:
-
Multi-step reaction with 2 steps
1: triphenylphosphine / tetrahydrofuran / 7.5 h / 45 °C
2: sodium carbonate / dioxane; H2O / 1 h
With
sodium carbonate; triphenylphosphine;
In
tetrahydrofuran; 1,4-dioxane; water;
2: Schotten-Baumann reaction;
DOI:10.1016/j.bmc.2004.10.060
