Desethyl Amiodarone Hydrochloride

Base Information

• Chemical Name: Desethyl Amiodarone Hydrochloride
• CAS No.: 96027-74-6
• Molecular Formula: C23H25 I2 N O3 . Cl H
• Molecular Weight: 653.71938
• Hs Code.: 29329990
• Mol file: 96027-74-6.mol

Synonyms:Methanone,(2-butyl-3-benzofuranyl)[4-[2-(ethylamino)ethoxy]-3,5-diiodophenyl]-,hydrochloride (9CI)

Chemical Property of Desethyl Amiodarone Hydrochloride

Chemical Property:

• Vapor Pressure: 8.51E-16mmHg at 25°C
• Melting Point: 176-1780C
• Boiling Point: 630.3°C at 760 mmHg
• Flash Point: 335°C
• PSA: 51.47000
• LogP: 7.39680
• Storage Temp.: -20°C Freezer, Under Inert Atmosphere
• Solubility.: DMSO (Slightly), Methanol (Slightly)

Purity/Quality:

97% ^*data from raw suppliers

Desethyl Amiodarone Hydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s): F,T
• Hazard Codes: F,T
• Statements: 11-23/24/25-39/23/24/25
• Safety Statements: 7-16-36/37-45

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Desethyl Amiodarone Hydrochloride (Amiodarone EP Impurity B) is a metabolite of Amiodarone, a non-selective ion channel blocker.

Technology Process of Desethyl Amiodarone Hydrochloride

There total 3 articles about Desethyl Amiodarone Hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

N-(2-chloroethyl)ethylamine hydrochloride (4535-87-9) + 2-n-butyl-3-(3',5'-diiodo-4'-hydroxybenzoyl)benzofuran (1951-26-4) → Desethylamiodarone hydrochloride (96027-74-6)

Guidance literature:

With potassium carbonate; In water; toluene; for 1h; Heating;

DOI:10.1124/jpet.106.108993

Reference yield:

{4-[2-(benzyl-ethyl-amino)-ethoxy]-3,5-diiodo-phenyl}-(2-butyl-benzofuran-3-yl)-methanone (1096359-59-9) → Desethylamiodarone hydrochloride (96027-74-6)

Guidance literature:

{4-[2-(benzyl-ethyl-amino)-ethoxy]-3,5-diiodo-phenyl}-(2-butyl-benzofuran-3-yl)-methanone; With carbonochloridic acid 1-chloro-ethyl ester; In 1,2-dichloro-ethane; for 2h; Reflux;

In methanol; for 1h; Reflux;

With hydrogenchloride; In water; ethyl acetate;

DOI:10.1016/j.bmcl.2008.08.013

Reference yield:

→ Desethylamiodarone hydrochloride (96027-74-6)

Guidance literature:

upstream raw materials:

N-(2-chloroethyl)ethylamine hydrochloride

2-n-butyl-3-(3',5'-diiodo-4'-hydroxybenzoyl)benzofuran

{4-[2-(benzyl-ethyl-amino)-ethoxy]-3,5-diiodo-phenyl}-(2-butyl-benzofuran-3-yl)-methanone