Synonyms:Ironperchlorate (Fe(ClO4)3) (6CI,7CI); Perchloric acid, iron(3+) salt (8CI,9CI);Ferric perchlorate; Ferric perchlorate (Fe(ClO4)3); Iron triperchlorate;Iron(3+) perchlorate; Iron(III) perchlorate
99% *data from raw suppliers
Iron(III) perchlorate hydrate crystalline, low chloride *data from reagent suppliers
The research focuses on the development of a novel three-component reaction for the synthesis of N-cyclohexyl-3-aryl-quinoxaline-2-amines, which are nitrogen-containing heterocyclic compounds with significant biological activity and applications in drug discovery and various chemical industries. The study utilizes a three-component condensation reaction catalyzed by ferric perchlorate, involving o-phenylenediamine, aromatic aldehydes, and cyclohexyl isocyanide, to produce the desired quinoxaline derivatives in good yields. The experiments were conducted by refluxing a mixture of the three reactants in acetonitrile with a catalytic amount of ferric perchlorate for 2 hours. The progress of the reactions was monitored by thin-layer chromatography (TLC), and the products were obtained without further purification after the reaction mixture was diluted, separated, and dried. The synthesized compounds were characterized using melting point determination, infrared spectroscopy (IR), proton and carbon nuclear magnetic resonance (1H NMR and 13C NMR), gas chromatography-mass spectrometry (GC/MS), and elemental analysis, which confirmed their structures and composition.
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