N-Methyl-N-(piperidin-4-yl)benzamide

Base Information

• Chemical Name: N-Methyl-N-(piperidin-4-yl)benzamide
• CAS No.: 64951-39-9
• Molecular Formula: C13H18N2O
• Molecular Weight: 218.299
• Hs Code.: 2933399090
• DSSTox Substance ID: DTXSID80505381
• Wikidata: Q82360450
• Mol file: 64951-39-9.mol

Synonyms:N-Methyl-N-(piperidin-4-yl)benzamide;64951-39-9;n-methyl-n-piperidin-4-ylbenzamide;N-METHYL-N-4-PIPERIDINYL-BENZAMIDE;SCHEMBL3809371;DTXSID80505381;N-methyl-N-4-piperidinylbenzamide;QJIVZURLHLXUMO-UHFFFAOYSA-N;AB9808;MFCD10565853;CS-0300374;EN300-7399666

Chemical Property of N-Methyl-N-(piperidin-4-yl)benzamide

Chemical Property:

• Melting Point: 128-130 °C
• Boiling Point: 370.7±35.0 °C(Predicted)
• PKA: 9.87±0.10(Predicted)
• PSA: 32.34000
• Density: 1.10±0.1 g/cm3(Predicted)
• LogP: 1.83940
• XLogP3: 1.5
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 218.141913202
• Heavy Atom Count: 16
• Complexity: 230

Purity/Quality:

99% ^*data from raw suppliers

N-Methyl-N-(piperidin-4-yl)benzamide 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CN(C1CCNCC1)C(=O)C2=CC=CC=C2

Technology Process of N-Methyl-N-(piperidin-4-yl)benzamide

There total 7 articles about N-Methyl-N-(piperidin-4-yl)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

1-benzyl-4-(N-methylbenzoylamino)piperidine hydrochloride → 4-(N-methylbenzoylamino)piperidine (64951-39-9)

Guidance literature:

With hydrogen; palladium on activated charcoal; In ethanol; water; for 66h; under 2660 Torr; Ambient temperature;

Reference yield:

1,1-dimethylethyl 4-[methyl(phenylcarbonyl)amino]-1-piperidinecarboxylate (1383342-71-9) → 4-(N-methylbenzoylamino)piperidine (64951-39-9)

Guidance literature:

1,1-dimethylethyl 4-[methyl(phenylcarbonyl)amino]-1-piperidinecarboxylate; With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 0.5h;

With ammonia; In methanol;

Reference yield:

N-Methyl-1-(phenylmethyl)-4-piperidinamine dihydrochloride + benzoyl chloride (98-88-4) → 4-(N-methylbenzoylamino)piperidine (64951-39-9)

Guidance literature:

With triethylamine; palladium on charcoal catalyst; In chloroform; acetic acid;

upstream raw materials:

benzoyl chloride

benzoic acid

4-methylamino-piperidine-1-carboxylic acid tert-butyl ester

1,1-dimethylethyl 4-[methyl(phenylcarbonyl)amino]-1-piperidinecarboxylate

Downstream raw materials:

4-(N-benzyl-N-methylamino)-piperidine

N-methyl-N-[1-(5-methyl-1H-pyrrolo[2,3-d]pyrimidin-4-yl)-4-piperidinyl]benzamide

Benzyl-methyl-(1-pyrimidin-2-yl-piperidin-4-yl)-amine

Refernces

• 1、 -. "N-Sulfamoyl-piperidineamides for the treatment or inhibition of obesity and related conditions". Page/Page column 22. . Retrieved 2010/11/27.
• 2、 Moragues,Prieto,Spickett,Vega,Salazar,Roberts. "Dopaminergic activity in a series of N-substituted 2-aminopyrimidines". . p. 951 - 964. Retrieved 2007/10/02.