2-(furan-2-ylmethylsulfinyl)-N-[3-[3-(piperidin-1-ylmethyl)phenoxy]propyl]acetamide

Base Information

Chemical Name:2-(furan-2-ylmethylsulfinyl)-N-[3-[3-(piperidin-1-ylmethyl)phenoxy]propyl]acetamide
CAS No.:108498-50-6
Molecular Formula:C₂₂H₃₀N₂O₄S
Molecular Weight:418.557
Hs Code.:
DSSTox Substance ID:DTXSID10910747
Nikkaji Number:J956.732A

Synonyms:FRG 8701;FRG-8701;N-(3-(3-(piperidinylmethyl)phenoxy)propyl)-2-(furfurylsulfinyl)acetamide

Suppliers and Price of 2-(furan-2-ylmethylsulfinyl)-N-[3-[3-(piperidin-1-ylmethyl)phenoxy]propyl]acetamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 3 raw suppliers

Chemical Property of 2-(furan-2-ylmethylsulfinyl)-N-[3-[3-(piperidin-1-ylmethyl)phenoxy]propyl]acetamide

Chemical Property:

Vapor Pressure:4.35E-18mmHg at 25°C
Boiling Point:675.2°Cat760mmHg
Flash Point:362.1°C
Density:1.226g/cm³
XLogP3:2.1
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:11
Exact Mass:418.19262862
Heavy Atom Count:29
Complexity:513

Purity/Quality:: 95% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1CCN(CC1)CC2=CC(=CC=C2)OCCCNC(=O)CS(=O)CC3=CC=CO3

Technology Process of 2-(furan-2-ylmethylsulfinyl)-N-[3-[3-(piperidin-1-ylmethyl)phenoxy]propyl]acetamide

There total 6 articles about 2-(furan-2-ylmethylsulfinyl)-N-[3-[3-(piperidin-1-ylmethyl)phenoxy]propyl]acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 53.0%

: 110-89-4
piperidine

1N-HCl: 1N-HCl

: 123855-56-1
N-[3-(3-formylphenoxy)propyl]-2-(furfurylsulfinyl)acetamide

: 108498-50-6
N-{3-[-3-(piperidinomethyl)phenoxy]propyl}-2-(furfurylsulfinyl)acetamide

Guidance literature:: With sodium borohydrid; In ethanol;

Reference yield:

: 73278-98-5
N-<3-<3-(1-piperidinylmethyl)phenoxy>propyl>amine

: 108498-50-6
N-{3-[-3-(piperidinomethyl)phenoxy]propyl}-2-(furfurylsulfinyl)acetamide

Guidance literature:: Multi-step reaction with 3 steps

1: 63 percent / 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride / CH₂Cl₂ / 12 h / Ambient temperature

2: K₂CO₃, KI / acetonitrile / Heating

3: KIO₄ / methanol; H₂O / 1 h / 100 °C

With potassium metaperiodate; potassium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; potassium iodide; In methanol; dichloromethane; water; acetonitrile;
DOI:10.1248/cpb.46.610