Acetamide, 2-[[5-[3-[[2-(3,4-dimethoxyphenyl)ethyl]amino]-2-hydroxypropoxy]-1,2,3, 4-tetrahydro-2-oxo-8-quinolinyl]oxy]-, monohydrochloride

Base Information

Chemical Name:Acetamide, 2-[[5-[3-[[2-(3,4-dimethoxyphenyl)ethyl]amino]-2-hydroxypropoxy]-1,2,3, 4-tetrahydro-2-oxo-8-quinolinyl]oxy]-, monohydrochloride
CAS No.:65023-07-6
Molecular Formula:C24H31N3O7.ClH
Molecular Weight:509.987
Hs Code.:

Acetamide,
2-[[5-[3-[[2-(3,4-dimethoxyphenyl)ethyl]amino]-2-hydroxypropoxy]-1,2,3,
4-tetrahydro-2-oxo-8-quinolinyl]oxy]-, monohydrochloride

Synonyms:

Suppliers and Price of Acetamide, 2-[[5-[3-[[2-(3,4-dimethoxyphenyl)ethyl]amino]-2-hydroxypropoxy]-1,2,3, 4-tetrahydro-2-oxo-8-quinolinyl]oxy]-, monohydrochloride

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of Acetamide, 2-[[5-[3-[[2-(3,4-dimethoxyphenyl)ethyl]amino]-2-hydroxypropoxy]-1,2,3, 4-tetrahydro-2-oxo-8-quinolinyl]oxy]-, monohydrochloride

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of Acetamide, 2-[[5-[3-[[2-(3,4-dimethoxyphenyl)ethyl]amino]-2-hydroxypropoxy]-1,2,3, 4-tetrahydro-2-oxo-8-quinolinyl]oxy]-, monohydrochloride

There total 11 articles about Acetamide, 2-[[5-[3-[[2-(3,4-dimethoxyphenyl)ethyl]amino]-2-hydroxypropoxy]-1,2,3, 4-tetrahydro-2-oxo-8-quinolinyl]oxy]-, monohydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 24.0%

: 80090-31-9
[3-(8-Carbamoylmethoxy-2-oxo-1,2,3,4-tetrahydro-quinolin-5-yloxy)-2-hydroxy-propyl]-[2-(3,4-dimethoxy-phenyl)-ethyl]-carbamic acid benzyl ester

: 65023-07-6
2-(5-{3-[2-(3,4-Dimethoxy-phenyl)-ethylamino]-2-hydroxy-propoxy}-2-oxo-1,2,3,4-tetrahydro-quinolin-8-yloxy)-acetamide; hydrochloride

Guidance literature:: With hydrogen; acetic acid; palladium; In methanol; for 2h; Ambient temperature;
DOI:10.1248/cpb.29.2166

Reference yield: 24.0%

: 120-20-7
2-(3,4-dimethoxyphenyl)-ethylamine

: 2-(5-Oxiranylmethoxy-2-oxo-1,2,3,4-tetrahydro-quinolin-8-yloxy)-acetamide

: 65023-07-6
2-(5-{3-[2-(3,4-Dimethoxy-phenyl)-ethylamino]-2-hydroxy-propoxy}-2-oxo-1,2,3,4-tetrahydro-quinolin-8-yloxy)-acetamide; hydrochloride

Guidance literature:: In methanol;
DOI:10.1248/cpb.29.2166

Reference yield:

: 59430-56-7
5,8-Dihydroxy-3,4-dihydro-2(1H)-quinolinone

: 65023-07-6
2-(5-{3-[2-(3,4-Dimethoxy-phenyl)-ethylamino]-2-hydroxy-propoxy}-2-oxo-1,2,3,4-tetrahydro-quinolin-8-yloxy)-acetamide; hydrochloride

Guidance literature:: Multi-step reaction with 9 steps

1: 48 percent / K₂CO₃ / acetone; H₂O / 4 h / Heating

2: 56 percent / K₂CO₃ / propan-2-ol / 5 h / 70 - 80 °C

3: 43.6 percent / methanol / 20 h / Ambient temperature

4: 77.2 percent / hydrogen / 10percent Pd-C / methanol; H₂O / 8 h / Ambient temperature

5: 96 percent / 10percent Na₂CO₃, NaOH / acetone; H₂O / 1.5 h / Ambient temperature

6: 100 percent / 2N NaOH / methanol / Ambient temperature

7: 73.8 percent / K₂CO₃ / acetone; H₂O / 9 h / Ambient temperature

8: 65 percent / 28percent NH₄OH

9: 24 percent / hydrogen, CH₃COOH / Pd / methanol / 2 h / Ambient temperature

With ammonium hydroxide; sodium hydroxide; hydrogen; sodium carbonate; potassium carbonate; acetic acid; palladium on activated charcoal; palladium; In methanol; water; isopropyl alcohol; acetone;
DOI:10.1248/cpb.29.2166