iodoaminopotentidine

Base Information

• Chemical Name: iodoaminopotentidine
• CAS No.: 126632-01-7
• Molecular Formula: C₂₆H₃₄IN₇O₂
• Molecular Weight: 603.506
• Mol file: 126632-01-7.mol

Synonyms:Benzamide,4-amino-N-[2-[[(cyanoamino)[[3-[3-(1-piperidinylmethyl)phenoxy]propyl]amino]methylene]amino]ethyl]-3-iodo-(9CI); Iodoaminopotentidine

Chemical Property of iodoaminopotentidine

Chemical Property:

• Boiling Point: °Cat760mmHg
• PKA: 13.53±0.46(Predicted)
• Flash Point: °C
• PSA: 131.29000
• Density: 1.47g/cm³
• LogP: 4.95018

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of iodoaminopotentidine

There total 3 articles about iodoaminopotentidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N-cyano-O-phenyl-N'-<3-<3-(1-piperidinylmethyl)phenoxy>propyl>isourea (98078-91-2,112528-14-0,112528-15-1) → N-<2-(4-amino-3-iodobenzamido)ethyl>-N'-cyano-N''-<3-<3-(1-piperidinylmethyl)phenoxy>propyl>guanidine (126632-01-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 90 percent / CH₂Cl₂

2: 1.) N,N'-carbonyldiimidazole (CDI) / 1.) THF, 1 h, 2.) THF, RT, 8 h

With 1,1'-carbonyldiimidazole; In dichloromethane;

DOI:10.1021/jm00090a013

Reference yield:

p-aminoethylbenzoate (94-09-7) → N-<2-(4-amino-3-iodobenzamido)ethyl>-N'-cyano-N''-<3-<3-(1-piperidinylmethyl)phenoxy>propyl>guanidine (126632-01-7)

Guidance literature:

Multi-step reaction with 3 steps

1: 97 percent / benzyltrimethylammonium dichloroiodate, CaCO₃ / CH₂Cl₂; methanol / 48 h

2: 98 percent / 10percent aq. KOH / 1 h / Heating

3: 1.) N,N'-carbonyldiimidazole (CDI) / 1.) THF, 1 h, 2.) THF, RT, 8 h

With potassium hydroxide; N,N,N-trimethylbenzenemethanaminium dichloroiodate; 1,1'-carbonyldiimidazole; calcium carbonate; In methanol; dichloromethane;

DOI:10.1021/jm00090a013

Reference yield:

3-iodobenzocaine (62875-84-7) → N-<2-(4-amino-3-iodobenzamido)ethyl>-N'-cyano-N''-<3-<3-(1-piperidinylmethyl)phenoxy>propyl>guanidine (126632-01-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 98 percent / 10percent aq. KOH / 1 h / Heating

2: 1.) N,N'-carbonyldiimidazole (CDI) / 1.) THF, 1 h, 2.) THF, RT, 8 h

With potassium hydroxide; 1,1'-carbonyldiimidazole;

DOI:10.1021/jm00090a013

upstream raw materials:

3-iodobenzocaine

N-cyano-O-phenyl-N'-<3-<3-(1-piperidinylmethyl)phenoxy>propyl>isourea

p-aminoethylbenzoate

Downstream raw materials:

N-<2-(4-azido-3-iodobenzamido)ethyl>-N'-cyano-N''-<3-<3-(1-piperidinylmethyl)phenoxy>propyl>guanidine

Refernces