5-Hydroxyuracil

Base Information

Chemical Name:5-Hydroxyuracil
CAS No.:20636-41-3
Molecular Formula:C4H4N2O3
Molecular Weight:128.087
Hs Code.:2933599090
European Community (EC) Number:243-932-5
NSC Number:90431
DSSTox Substance ID:DTXSID30174667
Nikkaji Number:J139.222K
Wikipedia:5-Hydroxyuracil
Wikidata:Q21099624
Metabolomics Workbench ID:54031
ChEMBL ID:CHEMBL1561505
Mol file:20636-41-3.mol

Synonyms:5-hydroxyuracil

Suppliers and Price of 5-Hydroxyuracil

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Usbiological
Isobarbituric Acid
100mg
$ 418.00

TRC
5-Hydroxy-2,4(1H,3H)-pyrimidinedione
500mg
$ 110.00

TRC
5-Hydroxy-2,4(1H,3H)-pyrimidinedione
100mg
$ 40.00

Sigma-Aldrich
Isobarbituric acid analytical standard
1 g
$ 121.00

American Custom Chemicals Corporation
2,4,5-TRIHYDROXYPYRIMIDINE 95.00%
1G
$ 164.18

Total 17 raw suppliers

Chemical Property of 5-Hydroxyuracil

Chemical Property:

Melting Point:>300oC (dec.)(lit.)
Boiling Point:534.5°Cat760mmHg
PKA:8.55±0.10(Predicted)
Flash Point:277°C
PSA：75.27000
Density:1.605g/cm³
LogP:-0.94750
Storage Temp.:Refrigerator
Solubility.:Aqueous Base (Slightly), DMSO (Slightly, Sonicated), Methanol (Slightly)
XLogP3:-1.1
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:0
Exact Mass:128.02219199
Heavy Atom Count:9
Complexity:196

Purity/Quality:

99% ^*data from raw suppliers

Isobarbituric Acid ^*data from reagent suppliers

Safty Information:

Pictogram(s): Xi
Hazard Codes:Xi
Statements: 36/37/38
Safety Statements: 26-36

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1=C(C(=O)NC(=O)N1)O
Uses 5-Hydroxy-2,4(1H,3H)-pyrimidinedione is used preparation and purification of Fluorouracil.

Technology Process of 5-Hydroxyuracil

There total 38 articles about 5-Hydroxyuracil which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 66-22-8,144104-68-7,18324-22-6,27072-01-1,2920-92-5,51953-19-6
uracil

: 20636-41-3
5-hydroxyuracil

Guidance literature:: With sodium hydroxide; sodium persulfate; at 22 ℃;
DOI:10.1039/a800135i

Reference yield:

: 66-22-8,144104-68-7,18324-22-6,27072-01-1,2920-92-5,51953-19-6
uracil

: 29410-13-7
5-hydroxy-hydantoin

: 120-89-8
parabanic acid

: 20636-41-3
5-hydroxyuracil

: 102636-37-3
5,6-dihydroxypyrimidine-2,4(1H,3H)-dione

: 35805-53-9
N-formyl-N'-glyoxylurea

: 585-05-7
oxaluric acid

Guidance literature:: With sonolysis; In water; at 25 ℃; for 2h; Product distribution; Mechanism; further reaction times, under air or under further gases;

Reference yield:

: 66-22-8,144104-68-7,18324-22-6,27072-01-1,2920-92-5,51953-19-6
uracil

: 504-07-4
5,6-dhydrouracil

: 20636-41-3
2,4,5-trihydroxypyrimidine

: 3683-34-9,3952-56-5,20433-38-9,112419-41-7,112419-42-8
cis-5,6-dihydroxydihydropyrimidine-2,4-dione

: 3683-34-9,3952-56-5,20433-38-9,112419-41-7,112419-42-8
trans-5,6-dihydroxydihydropyrimidine-2,4-dione

Guidance literature:: With nickel(II) sulphate; In water; Product distribution; Irradiation; various Ni(II) compound as reagents;
DOI:10.1039/f19848001205